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Ondexxya 200 mg powder for solution for infusion

DRUG4 trials

Sponsors

Astrazeneca AB, Astrazeneca AB, Janssen - Cilag International, Medical University Of Gdansk, Amsterdam UMC Stichting

Conditions

Acute ischemic strokeAtrial FibrillationReversal of anticoagulation effect in patients on a FXa inhibitor (apixabanRoux-en-Y gastric bypassand who have a major risk of bleeding.or edoxaban) who require urgent surgery or procedurerivaroxaban

Phase 2

A multicentre, parallel group, randomised, double blind, placebo-controlled, phase II study evaluating the efficacy and safety of reperfusion thrombolytic therapy with intravenous recombinant tissue plasminogen activator (rtPA) for ischaemic stroke in patients on the non-vitamin K antagonist oral anticoagulant after reversing anticoagulant activity with the specific antidote
RecruitingCTIS2024-518509-17-00
Medical University Of GdanskAcute ischemic stroke
Start: 2022-01-10Target: 300Updated: 2024-12-09

Phase 3

A Phase 3, Randomized, Double-Blind, Double-Dummy, Parallel Group, Active-Controlled Study to Evaluate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, Versus Apixaban in Participants with Atrial Fibrillation
Active, not recruitingCTIS2022-501419-15-00
Janssen - Cilag InternationalAtrial Fibrillation
Start: 2023-08-23Target: 8867Updated: 2025-10-29
A Randomized Study of Andexanet Alfa Compared to Usual Care in Patients Receiving a Factor Xa Inhibitor who Require Urgent Surgery or Procedure (ANNEXA-RS)
CompletedCTIS2022-501353-37-00
Astrazeneca AB, Astrazeneca ABand who have a major risk of bleeding., or edoxaban) who require urgent surgery or procedure, Reversal of anticoagulation effect in patients on a FXa inhibitor (apixaban +1
End: 2024-06-13Target: 467Updated: 2024-02-19

Phase 4

Weight-loss Effects aNd absorption of Direct oral anticoagulants in roux-en-Y gastric bypass patients: a prospective study (WENDY)
Not yet recruitingCTIS2024-519737-30-00
Amsterdam UMC StichtingRoux-en-Y gastric bypass
Target: 30Updated: 2025-05-28