On Day 1, catheter will be inserted into the targeted site with the method of stereotactic neurosurgery. After the MR imaging, infusion of the drug

2 trials

Sponsors

Tominaga Teiji, Tohoku University

Conditions

initially diagnosed pediatric diffuse intrinsic pontine glioma (DIPG), adult brainstem glioma Malignancyrecurrent glioma at brainstem

Phase 2

Phase II study of Convection-enhanced delivery of Nimustine Hydrochloride combined with systemic Temozolomide against recurrent gliomas at brainstem

Active, not recruitingJPRN-UMIN000025033

Tohoku Universityrecurrent glioma at brainstem

Start: 2016-12-01Target: 35Updated: 2026-06-29

Phase II multicenter investigator initiated trial of Convection-enhanced delivery of Nimustine Hydrochloride against brainstem gliomas

Active, not recruitingJPRN-jRCT2021190003

Tominaga Teijiinitially diagnosed pediatric diffuse intrinsic pontine glioma (DIPG), adult brainstem glioma Malignancy

Start: 2018-05-07Target: 30Updated: 2026-06-29

Related Papers

DDEL-08. A multicenter phase II trial of convection-enhanced delivery of ACNU in children with DIPG: Comparison with Japanese historical control and examination of patient selection bias

Neuro-Oncology2025-11-01

A Multicenter Phase II Trial of Nimustine Hydrochloride Administered via Convection‐Enhanced Delivery in Children With DIPG

Cancer Science2025-03-272 citations

Phase II single-arm, multi-center, physician-initiated clinical trial of convection-enhanced delivery of nimustine hydrochloride (ACNU) against diffuse intrinsic pontine gliomas.

Journal of Clinical Oncology2022-06-012 citations