Omaveloxolone
Sponsors
Biogen
Conditions
Friedreich AtaxiaHealth Adult SubjectsHealthyHealthy Adult SubjectsHealthy VolunteerMelanomaMetastatic or Incurable Non-small Cell Lung CancerRelapsed, Refractory Melanoma
Phase 1
RTA 408 in the Treatment of Advanced Solid Tumors (NSCLC & Melanoma) - DISCOVER
CompletedNCT02029729
Start: 2013-12-31End: 2015-10-01Updated: 2025-05-29
A Pharmacokinetic Study of Omaveloxolone in Healthy Volunteers
CompletedNCT03664453
Start: 2018-10-29End: 2018-11-20Updated: 2025-05-30
A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone
CompletedNCT04008186
Start: 2019-06-14End: 2019-08-28Updated: 2025-05-30
An Open-label DDI Study of Omaveloxolone in Healthy Subjects
CompletedNCT05909644
Start: 2023-07-05End: 2023-08-30Updated: 2025-05-30
A TQTc Study for Omaveloxolone
CompletedNCT05927649
Start: 2023-07-11End: 2023-09-01Updated: 2025-05-30
A Study to Find Out How BIIB141 (Omaveloxolone) is Processed in the Body and to Learn More About Its Safety in Participants With Friedreich's Ataxia Aged 2 to 15 Years Old
RecruitingNCT06054893
Start: 2024-07-01End: 2030-11-22Target: 35Updated: 2026-01-07
A Study to Find Out How BIIB141 (Omaveloxolone) Moves From the Blood Into the Breastmilk of Healthy Women Who Are Breastfeeding or Pumping Milk
CompletedNCT06612879
Start: 2024-10-18End: 2025-04-08Updated: 2025-04-22
A Study to Learn How BIIB141 (Omaveloxolone) is Processed in the Body When Taken as Capsules Compared to Sprinkled on Yogurt in Healthy Adults Aged 18 to 55
CompletedNCT07019064
Start: 2025-06-11End: 2025-08-19Updated: 2025-09-22
A Study to Learn if Taking BIIB141 (Omaveloxolone) Affects How Omeprazole is Processed in the Body and About BIIB141's Safety in Healthy Adults Aged 18 to 55
CompletedNCT07149415
Start: 2025-09-02End: 2025-10-16Updated: 2025-10-23
A Study to Learn How the Body Processes BIIB141 (Omaveloxolone) When Taken as a Capsule or as a Tablet Dissolved in Liquid, and to Learn About Its Safety in Healthy Adults Ages 18 to 55
RecruitingNCT07297199
Start: 2025-12-12End: 2026-04-17Target: 70Updated: 2026-02-12
Phase 3
Unknown Phase
Expanded Access to Omaveloxolone for Melanoma for Patients Previously Enrolled in 408-C-1401
NCT03593499
Updated: 2025-05-31
A Study to Learn More About the Long-Term Safety of BIIB141 (Omaveloxolone) in Participants With Friedreich's Ataxia Who Are Prescribed it by Their Own Doctors
RecruitingNCT06623890
Start: 2024-12-12End: 2029-10-01Target: 300Updated: 2025-04-10
A Study to Learn How BIIB141 (Omaveloxolone) Affects the Health of Participants With Friedrich's Ataxia Who Took it During Pregnancy and/or During Breastfeeding and About the Health of Their Babies
RecruitingNCT06628687
Start: 2026-10-26End: 2035-04-30Target: 20Updated: 2025-06-26