Omadacycline Oral Tablet

DRUG5 trials

Sponsors

Paratek Pharmaceuticals Inc, Zai Lab (Hong Kong), Ltd., Vancouver Coastal Health, Montefiore Medical Center

Conditions

Bacterial InfectionsHealthy VolunteerMycobacterium Abscessus InfectionMycobacterium Infections, NontuberculousMycoplasma Genitalium InfectionNon-Tuberculous Mycobacterial (NTM) PneumoniaNontuberculous Mycobacterial Lung DiseaseNontuberculous Mycobacterial Pulmonary Infection

Phase 1

Study to Evaluate the PK of IV and PO Omadacycline in Children and Adolescents With Suspected or Confirmed Bacterial Infections

CompletedNCT05217537

Paratek Pharmaceuticals IncBacterial Infections

Start: 2022-04-06End: 2025-02-27Updated: 2026-03-09

A Study to Compare the Effect of Omadacycline Versus Moxifloxacin in Healthy Adult Volunteers

CompletedNCT06462326

Zai Lab (Hong Kong), Ltd.Healthy Volunteer

Start: 2024-04-16End: 2024-09-29Updated: 2024-11-01

Bacteriophage Therapy for Mycobacterium Abscessus Pulmonary Infection

Enrolling by invitationNCT07228702

Vancouver Coastal HealthMycobacterium Abscessus Infection, Non-Tuberculous Mycobacterial (NTM) Pneumonia

Start: 2026-01-11End: 2027-10-01Target: 1Updated: 2026-06-03

Phase 2

Oral Omadacycline vs. Placebo in Adults With NTM Pulmonary Disease Caused by Mycobacterium Abscessus Complex (MABc)

CompletedNCT04922554

Paratek Pharmaceuticals IncMycobacterium Abscessus Infection, Mycobacterium Infections, Nontuberculous, Nontuberculous Mycobacterial Lung Disease +1

Start: 2021-10-15End: 2024-07-17Updated: 2025-07-30

Omadacycline for Treatment Refractory Mycoplasma Genitalium Urethritis

Not yet recruitingNCT07853742

Montefiore Medical CenterMycoplasma Genitalium Infection, Urethritis

Start: 2027-01-01End: 2027-07-01Target: 10Updated: 2026-10-29

Related Papers

336. Microbiological Outcomes of Oral Omadacycline Treatment in Adults with Nontuberculous Mycobacterial Pulmonary Disease (NTM-PD) Caused by Mycobacterium abscessus complex (MABc): Results from a Phase 2, Double-blind, Randomized, Placebo-controlled, Multi-center Trial

Open Forum Infectious Diseases2026-01-01

A Phase 2, Double-blind, Randomized, Placebo-controlled, Multi-center Study to Evaluate the Efficacy, Safety, and Tolerability of Oral Omadacycline in Adults With Nontuberculous Mycobacterial Pulmonary Disease (NTM PD) Caused by Mycobacterium Abscessus Complex (MABc)

American Journal of Respiratory and Critical Care Medicine2025-05-012 citations

Evaluation of omadacycline against intracellular <i>Mycobacterium abscessus</i> in an infection model in human macrophages

JAC-Antimicrobial Resistance2023-09-045 citations