Olpasiran
Sponsors
Amgen Inc., Amgen
Conditions
Atherosclerotic Cardiovascular DiseaseBasic ScienceCardiovascular DiseaseElevated Serum Lipoprotein(a)Hepatic ImpairmentRenal Impairment
Phase 1
A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Olpasiran in Chinese Participants With Elevated Serum Lipoprotein(a)
CompletedNCT04987320
Start: 2021-07-28End: 2022-03-18Updated: 2025-02-10
A Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of Olpasiran in Participants With Various Degrees of Hepatic Impairment
CompletedNCT05481411
Start: 2022-09-13End: 2023-05-31Updated: 2025-10-15
A Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of Olpasiran in Participants With Normal Renal Function and Participants With Various Degrees of Renal Impairment
CompletedNCT05489614
Start: 2022-09-13End: 2023-12-19Updated: 2025-11-26
A Study to Assess the Effect of Olpasiran on QT/QTc Intervals in Healthy Participants
CompletedNCT06411860
Start: 2024-09-12End: 2024-12-11Updated: 2025-10-27
Phase 2
Phase 3
Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial
Active, not recruitingNCT05581303
Start: 2022-12-14End: 2028-03-31Updated: 2026-02-27
OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
RecruitingNCT07136012
Start: 2025-08-22End: 2031-10-20Target: 11000Updated: 2026-08-21
Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial
RecruitingNCT07293260
Start: 2026-03-23End: 2028-06-15Target: 406Updated: 2026-04-16
A Double-blind, Randomized, Placebo-controlled, Multi-center Study Evaluating the Safety, Tolerability, and Effect of Olpasiran on Coronary Artery Plaque Burden Assessed by Coronary Computed Tomography Angiography in Participants With Stable Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein(a)
Not yet recruitingCTIS2025-521117-88-00
Target: 178Updated: 2026-01-12