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OH2 injection

BIOLOGICAL8 trials

Sponsors

Binhui Biopharmaceutical Co., Ltd.

Conditions

Advanced Bladder CarcinomaAdvanced Liver CancerCentral Nervous System TumorsMelanomaNon-muscle-invasive Bladder CancerPancreatic CancerSolid Tumor

Phase 1

OH2 Injection in Solid Tumors
RecruitingNCT04386967
Binhui Biopharmaceutical Co., Ltd.Melanoma, Solid Tumor
Start: 2018-11-22End: 2026-12-13Target: 30Updated: 2025-07-25
OH2 Injection in Combination With HX008 for Melanoma.
RecruitingNCT04616443
Binhui Biopharmaceutical Co., Ltd.Melanoma
Start: 2020-12-01End: 2025-11-30Target: 60Updated: 2025-07-24
OH2 Oncolytic Viral Therapy in Pancreatic Cancer
TerminatedNCT04637698
Binhui Biopharmaceutical Co., Ltd.Pancreatic Cancer
Start: 2021-02-02End: 2023-05-04Updated: 2023-11-24
OH2 Oncolytic Viral Therapy in Non-Muscle-Invasive Bladder Cancer
RecruitingNCT05232136
Binhui Biopharmaceutical Co., Ltd.Non-muscle-invasive Bladder Cancer
Start: 2022-07-11End: 2025-10-31Target: 30Updated: 2024-08-12
OH2 Oncolytic Viral Therapy in Central Nervous System Tumors
RecruitingNCT05235074
Binhui Biopharmaceutical Co., Ltd.Central Nervous System Tumors
Start: 2021-11-16End: 2026-06-16Target: 28Updated: 2025-07-25
OH2 Oncolytic Viral Therapy Via Transcatheter Intraarterial Infusion in Patients with Advanced Liver Cancer
RecruitingNCT05698459
Binhui Biopharmaceutical Co., Ltd.Advanced Liver Cancer
Start: 2023-05-05End: 2026-01-31Target: 12Updated: 2024-12-20
OH2 Administered by Intratumoral Injection
Not yet recruitingNCT05954091
Binhui Biopharmaceutical Co., Ltd.Solid Tumor
Start: 2025-09-01End: 2028-01-01Target: 29Updated: 2024-12-27

Phase 2

OH2 Oncolytic Viral Therapy in Advanced Bladder Cancer
TerminatedNCT05248789
Binhui Biopharmaceutical Co., Ltd.Advanced Bladder Carcinoma
Start: 2022-05-25End: 2024-10-28Updated: 2025-08-03

Related Papers

Phase Ib/II clinical trial of oncolytic virus intravesical irrigation for preventing recurrence after TURBT in patients with recurrent high-risk NMIBC.
Journal of Clinical Oncology2025-02-10
Oncolytic virus OH2 extends survival in patients with PD-1 pretreated melanoma: phase Ia/Ib trial results and biomarker insights
Journal for ImmunoTherapy of Cancer2025-02-0115 citations
OH2 oncolytic virus: A novel approach to glioblastoma intervention through direct targeting of tumor cells and augmentation of anti-tumor immune responses
Cancer Letters2024-03-2519 citations
A phase Ia/Ib study evaluating the safety and efficacy of intratumorally administrated OH2, an oncolytic herpes simplex virus 2, in unresected stage IIIC to IV melanoma patients.
Journal of Clinical Oncology2022-06-013 citations