Ocrevus
Sponsors
F. Hoffmann-La Roche AG, Amgen Inc., F. HOFFMANN-LA ROCHE LTD, Kessler Foundation, State University of New York at Buffalo
Conditions
Multiple SclerosisMultiple Sclerosis (MS)Multiple Sclerosis, Relapsing-RemittingNeurological DiseaseProgressive Multiple Sclerosis
MSRelapsing-Remitting Multiple Sclerosis (RRMS)Relapsing-remitting Multiple SclerosisSecondary-progressive Multiple Sclerosis
Phase 2
Study to Assess the Efficacy of Mayzent on Microglia in Secondary Progressive Multiple Sclerosis
TerminatedNCT04925557
Start: 2021-11-13End: 2023-08-05Updated: 2025-05-13
A Phase II, Randomized, Open-Label, Parallel Group, Multicenter Study to Assess Bioequivalence of Two Subcutaneous Formulations of Ocrelizumab in Patients with Multiple Sclerosis
RecruitingCTIS2024-517980-22-00
Start: 2025-12-10Target: 86Updated: 2025-12-10
An Open-Label Study to Evaluate Pharmacokinetics, Safety, Tolerability, Immunogenicity and Pharmacodynamic Effects of Subcutaneous Ocrelizumab Administration in Children and Adolescents with Relapsing-Remitting Multiple Sclerosis
Not yet recruitingCTIS2025-524164-37-00
Target: 6Updated: 2026-06-23
Phase 3
An Open-Label, Multicenter Extension Study Providing Continued Access to Treatment in Patients with a Neurological Disease Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Study and without Access to A Post Trial Access Program
WithdrawnCTIS2023-507633-21-00
Target: 196Updated: 2024-04-26
A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study to Investigate the Pharmacokinetics, Pharmacodynamics, Safety and Radiological and Clinical Effects of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab in Patients with Multiple Sclerosis
CompletedCTIS2023-505975-54-00
Start: 2022-03-28End: 2025-06-06Target: 153Updated: 2025-04-01
A Randomized, Double-blind, Parallel-group Study to Compare Pharmacokinetics, Pharmacodynamics, Clinical Effects, and Safety between ABP 692 and Ocrevus® (Ocrelizumab) in Subjects with Relapsing-remitting Multiple Sclerosis
RecruitingCTIS2024-512914-16-00
Start: 2025-09-12Target: 370Updated: 2025-12-01
Consonance
Active, not recruitingLBCTR2020030186
Start: 2019-05-29Target: 10Updated: 2026-02-02
A PHASE III, OPEN-LABEL, SINGLE-ARM, MULTI-CENTER STUDY TO EVALUATE THE SAFETY AND USE OF AN ON-BODY DELIVERY SYSTEM FOR THE SUBCUTANEOUS HOME ADMINISTRATION OF OCRELIZUMAB IN PATIENTS WITH MULTIPLE SCLEROSIS
RecruitingCTIS2025-523726-40-00
Target: 36Updated: 2026-06-26