Observation Activity

OTHER5 trials

Sponsors

National Cancer Institute (NCI), Mayo Clinic, NRG Oncology

Conditions

Chronic Lymphocytic LeukemiaClinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Human Papillomavirus-Related Oropharyngeal Squamous Cell CarcinomaLocally Advanced Unresectable Pancreatic Ductal AdenocarcinomaLung Non-Small Cell CarcinomaLung Non-Small Cell Squamous Carcinoma

Phase 2

De-Escalated Adjuvant and Definitive Radiation Therapy Informed by DART 2.0 ctHPV-DNA

RecruitingNCT05541016

Mayo ClinicClinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 +4

Start: 2023-02-21End: 2029-08-01Target: 455Updated: 2025-11-04

Phase 3

Nivolumab After Surgery and Chemotherapy in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer (An ALCHEMIST Treatment Trial)

Active, not recruitingNCT02595944

National Cancer Institute (NCI)Stage IB Lung Non-Small Cell Carcinoma AJCC v7, Stage IIIA Lung Non-Small Cell Cancer AJCC v7, Stage II Lung Non-Small Cell Cancer AJCC v7

Start: 2016-07-22End: 2026-12-31Target: 903Updated: 2026-04-03

Testing the Addition of a New Anti-cancer Drug, Venetoclax, to the Usual Treatment (Ibrutinib and Obinutuzumab) in Untreated, Older Patients With Chronic Lymphocytic Leukemia

Active, not recruitingNCT03737981

National Cancer Institute (NCI)Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

Start: 2019-01-31End: 2026-12-29Updated: 2026-04-03

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

RecruitingNCT04267848

National Cancer Institute (NCI)Lung Non-Small Cell Carcinoma, Lung Non-Small Cell Squamous Carcinoma, Lung Non-Squamous Non-Small Cell Carcinoma +3

Start: 2020-06-16End: 2027-01-31Target: 1210Updated: 2026-04-03

Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

RecruitingNCT06958328

NRG OncologyLocally Advanced Unresectable Pancreatic Ductal Adenocarcinoma, Stage III Pancreatic Cancer AJCC v8, Stage II Pancreatic Cancer AJCC v8 +1

Start: 2025-08-21End: 2030-10-21Target: 356Updated: 2026-02-02

Related Papers

Results of a phase 3 study of IVO vs IO for previously untreated older patients (pts) with chronic lymphocytic leukemia (CLL) and impact of COVID-19 (Alliance).

Journal of Clinical Oncology2023-06-0113 citations

A041702: A Randomized Phase III Study of Ibrutinib Plus Obinutuzumab Versus Ibrutinib Plus Venetoclax and Obinutuzumab in Untreated Older Patients (≥ 70 Years of Age) with Chronic Lymphocytic Leukemia (CLL)

Blood2021-11-053 citations

Integration of Immunotherapy into Adjuvant Therapy for Resected Non-Small-Cell Lung Cancer: ALCHEMIST Chemo-Io (ACCIO)

Immunotherapy2021-04-2125 citations

The evolving role of Bruton's tyrosine kinase inhibitors in chronic lymphocytic leukemia.

2021-01-3011 citations

Alliance A041702: A Randomized Phase III Study of Ibrutinib Plus Obinutuzumab Versus Ibrutinib Plus Venetoclax and Obinutuzumab in Untreated Older Patients (≥ 70 Years of Age) with Chronic Lymphocytic Leukemia (CLL)

Blood2019-11-136 citations

EA5142 adjuvant nivolumab in resected lung cancers (ANVIL).

Journal of Clinical Oncology2018-05-2041 citations

EA5142 adjuvant nivolumab in resected lung cancers (ANVIL): The newest study in the ALCHEMIST platform.

Journal of Clinical Oncology2017-05-2012 citations