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Obicetrapib

DRUG13 trials

Sponsors

NewAmsterdam Pharma B.V., NewAmsterdam Pharma

Conditions

Adults with Type 2 Diabetes and/or Metabolic Syndrome on guideline recommended lipid lowering therapy and elevated low-density lipoprotein cholesterol (LDL-C)Atherosclerotic Cardiovascular DiseaseDyslipidemiaDyslipidemiasEarly Alzheimer's DiseaseFamilial HypercholesterolemiaGenetic Disease, InbornHealthy

Phase 1

Phase 2

Phase 3

Randomized Study to Evaluate the Effect of Obicetrapib on Top of Maximum Tolerated Lipid-Modifying Therapies
CompletedNCT05142722
NewAmsterdam PharmaAtherosclerotic Cardiovascular Disease, Dyslipidemias, Familial Hypercholesterolemia +2
Start: 2021-12-15End: 2024-09-26Updated: 2025-09-19
Cardiovascular Outcome Study to Evaluate the Effect of Obicetrapib in Patients With Cardiovascular Disease
Active, not recruitingNCT05202509
NewAmsterdam PharmaAtherosclerotic Cardiovascular Disease
Start: 2022-02-07End: 2026-11-30Updated: 2024-06-04
Evaluate the Effect of Obicetrapib in Patients With HeFH on Top of Maximum Tolerated Lipid-Modifying Therapies.
CompletedNCT05425745
NewAmsterdam PharmaDyslipidemias, Familial Hypercholesterolemia, Genetic Disease, Inborn +6
Start: 2022-07-25End: 2024-05-28Updated: 2025-06-11
Obicetrapib and Cardiovascular Outcomes: A Placebo-Controlled, Double-Blind, Randomized Phase 3 Study to Evaluate the Effect of 10 mg Obicetrapib in Participants With Atherosclerotic Cardiovascular Disease (ASCVD) Who are Not Adequately Controlled Despite Maximally Tolerated Lipid-Modifying Therapies
Active, not recruitingCTIS2023-507795-51-00
NewAmsterdam Pharma B.V.atherosclerotic heart and blood vessel disease (the narrowing of arteries from buildup of plague
Start: 2022-05-17Target: 4094Updated: 2026-01-27
A Placebo-Controlled, Double-Blind, Randomized, Phase 3 Study to Evaluate the Effect of Obicetrapib 10 mg and Ezetimibe 10 mg Fixed-Dose Combination or Obicetrapib 10 mg Daily on Top of Guideline-Recommended Lipid-Lowering Therapy in Participants With Type 2 Diabetes and/or Metabolic Syndrome (RUBENS trial)
Not yet recruitingCTIS2025-521936-12-00
NewAmsterdam Pharma B.V.Adults with Type 2 Diabetes and/or Metabolic Syndrome on guideline recommended lipid lowering therapy and elevated low-density lipoprotein cholesterol (LDL-C)
Target: 118Updated: 2026-04-01

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