NPSP558

DRUG4 trials

Sponsors

Shire

Conditions

Hypoparathyroidism

Phase 3

Use of NPSP558 in the Treatment of Hypoparathyroidism

CompletedNCT00732615

ShireHypoparathyroidism

Start: 2008-12-18End: 2011-09-28Updated: 2021-06-03

Study of Safety and Efficacy of a rhPTH[1-84] of Fixed Doses of 25 and 50 mcg in Adults With Hypoparathyroidism (RELAY)

CompletedNCT01268098

ShireHypoparathyroidism

Start: 2011-02-09End: 2011-11-11Updated: 2021-06-11

A Open-label Study Investigating the Safety and Tolerability of NPSP558, a Recombinant Human Parathyroid Hormone (rhPTH [1-84]), for the Treatment of Adults With Hypoparathyroidism - A Clinical Extension Study (RACE)

CompletedNCT01297309

ShireHypoparathyroidism

Start: 2011-04-06End: 2018-06-08Updated: 2021-05-25

A Study to Investigate the Safety and Tolerability of NPSP558, for the Treatment of Adults With Hypoparathyroidism - A Clinical Extension Study in Hungary

CompletedNCT01455181

ShireHypoparathyroidism

Start: 2011-08-19End: 2012-04-26Updated: 2021-06-11

Related Papers

Open-label extension of a randomized trial investigating safety and efficacy of rhPTH(1–84) in hypoparathyroidism

JBMR Plus2024-01-055 citations

Five-Year Estimated Glomerular Filtration Rate in Adults with Chronic Hypoparathyroidism Treated with rhPTH(1-84): A Retrospective Cohort Study.

2022-08-265 citations

The risk of chronic kidney disease development in adult patients with chronic hypoparathyroidism treated with rhPTH(1‐84): A retrospective cohort study

Clinical Endocrinology2022-08-1712 citations

Lower Risk of Cardiovascular Events in Adult Patients with Chronic Hypoparathyroidism Treated with rhPTH(1-84): A Retrospective Cohort Study.

2022-06-115 citations

Change in Estimated Glomerular Filtration Rate in Adult Patients With Chronic Hypoparathyroidism Treated With rhPTH(1–84) Compared With a Historical Control Cohort

Journal of the Endocrine Society2021-05-012 citations

Risk of Chronic Kidney Disease in Adult Patients With Chronic Hypoparathyroidism Treated With rhPTH(1–84) Compared With a Historical Control Cohort

Journal of the Endocrine Society2021-05-011 citations

Cardiovascular Events in Adult Patients With Chronic Hypoparathyroidism Treated With rhPTH(1–84) Compared With a Historical Control Cohort

Journal of the Endocrine Society2021-05-011 citations

Serum Calcium Levels in Adult Patients With Chronic Hypoparathyroidism Treated With rhPTH(1–84) Compared With a Historical Control Cohort

Journal of the Endocrine Society2021-05-01

Five-year Estimated Glomerular Filtration Rate in Patients With Hypoparathyroidism Treated With and Without rhPTH(1–84)

The Journal of Clinical Endocrinology & Metabolism2020-08-0129 citations

OR30-1 Safety and Efficacy of Recombinant Human Parathyroid Hormone 1-84 for the Treatment of Adults with Chronic Hypoparathyroidism: Six-Year Results of the RACE Study

Journal of the Endocrine Society2019-04-012 citations

Safety and Efficacy of Recombinant Human Parathyroid Hormone in Adults With Hypoparathyroidism Randomly Assigned to Receive Fixed 25-μg or 50-μg Daily Doses

Clinical Therapeutics2017-09-2120 citations

Efficacy and safety of recombinant human parathyroid hormone (1-84) in hypoparathyroidism (REPLACE): a double-blind, placebo-controlled, randomised, phase 3 study.

2013-10-07165 citations