No nitrous oxide

DRUG2 trials

Sponsors

Austin Health, Bayside Health

Conditions

AnesthesiaCoronary Artery Disease

Phase 4

Measurement of the Second Gas Effect on Sevoflurane in Anaesthetised Patients

CompletedNCT00321191

Austin HealthAnesthesia

Start: 2006-05-31End: 2006-09-30Updated: 2015-06-24

The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial

CompletedNCT00430989

Bayside HealthCoronary Artery Disease

Start: 2007-04-01End: 2013-09-01Updated: 2026-01-20

Related Papers

Integrating machine learning and pathway modelling to explore factors associated with chronic post-surgical pain and quality of life: a secondary observational analysis of the ENIGMA-II trial

BJA Open2026-06-17

Intraoperative dexamethasone does not increase the risk of postoperative wound infection: a propensity score-matched post hoc analysis of the ENIGMA-II trial (EnDEX).

2017-02-0123 citations

Chronic postsurgical pain in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II trial.

2016-12-0135 citations

The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial.

2014-10-01134 citations