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NK Cell Infusion

BIOLOGICAL7 trials

Sponsors

M.D. Anderson Cancer Center, St. Jude Children's Research Hospital, Institut Paoli-Calmettes, National Cancer Institute (NCI), Instituto de Investigación Hospital Universitario La Paz

Conditions

Acute Lymphoblastic LeukemiaAcute Myeloid Leukaemia (AML)Acute Myeloid LeukemiaBrain TumorsChronic Myelogenous LeukemiaDisorder Related to TransplantationHematological MalignancyJuvenile Myelomonocytic Leukemia

Phase 1

Immunotherapy With NK Cell, Rituximab and Rhu-GMCSF in Non-Myeloablative Allogeneic Stem Cell Transplantation
CompletedNCT00383994
M.D. Anderson Cancer CenterDisorder Related to Transplantation, Leukemia, Lymphoid Malignancies +2
Start: 2006-09-30End: 2019-07-22Updated: 2019-07-31
Pilot Study of Haploidentical Natural Killer Cell Infusions for Poor Prognosis Non-AML Hematologic Malignancies
CompletedNCT00697671
St. Jude Children's Research HospitalAcute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, Juvenile Myelomonocytic Leukemia +2
Start: 2007-03-31End: 2013-05-31Updated: 2013-07-16
Genetically Modified Haploidentical Natural Killer Cell Infusions for B-Lineage Acute Lymphoblastic Leukemia
CompletedNCT00995137
St. Jude Children's Research HospitalLymphoblastic Leukemia, Acute
Start: 2009-10-31End: 2014-05-31Updated: 2017-04-26
Phase I of Infusion of Selected Donor NK Cells After Allogeneic Stem Cell Transplantation
CompletedNCT01853358
Institut Paoli-CalmettesHematological Malignancy
Start: 2013-04-30End: 2018-03-15Target: 17Updated: 2018-07-12
NK White Blood Cells and Interleukin in Children and Young Adults With Advanced Solid Tumors
CompletedNCT01875601
National Cancer Institute (NCI)Brain Tumors, Neuroblastoma, Pediatric Cancers +2
Start: 2013-06-11End: 2015-09-08Updated: 2026-02-17

Phase 2

NK Cells as Consolidation Therapy of Acute Myeloid Leukemia in Children/Adolescents
CompletedNCT02763475
Instituto de Investigación Hospital Universitario La PazAcute Myeloid Leukemia, Leukemia, Myeloid Leukemia
Start: 2016-05-31End: 2020-08-31Updated: 2020-10-05
NK Cell Infusion for Remission Consolidation in AML: A Phase II Trial
Not yet recruitingNCT06783478
Hospital de Clinicas de Porto AlegreAcute Myeloid Leukaemia (AML)
Start: 2025-04-01End: 2027-12-31Target: 98Updated: 2025-01-20

Related Papers

621 A phase I study of autologous activated NK cells ± rhIL15 in children and young adults with refractory solid tumors
Regular and Young Investigator Award Abstracts2023-10-311 citations
Phase 2 Clinical Trial of Infusing Haploidentical K562-mb15-41BBL-Activated and Expanded Natural Killer Cells as Consolidation Therapy for Pediatric Acute Myeloblastic Leukemia.
2021-01-2513 citations
Natural Killer Cell-Based Immunotherapy against Solid Cancer
OALib2021-01-011 citations
Phase 1 Trial of Prophylactic Donor-Derived IL-2 Activated NK Cell Infusion after Allogeneic Hematopoietic Stem Cell Transplantation from a Matched Sibling Donor
Blood2020-11-051 citations
Study protocol for a phase II, multicentre, prospective, non-randomised clinical trial to assess the safety and efficacy of infusing allogeneic activated and expanded natural killer cells as consolidation therapy for paediatric acute myeloblastic leukaemia
BMJ Open2020-01-0114 citations