Niraparib Placebo Tablets
Sponsors
Glaxosmithkline Research & Development Limited, Tesaro Inc.
Conditions
BreastLung CancerNeoplasmsNon-Small CellRecurrent or primary advanced (Stage III or IV) endometrial cancer
Phase 3
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Comparing Niraparib Plus Pembrolizumab Versus Placebo Plus Pembrolizumab as Maintenance Therapy in Participants Whose Disease has Remained Stable or Responded to First-Line Platinum Based Chemotherapy with Pembrolizumab for Stage IIIB/IIIC or IV Non-Small Cell Lung Cancer (ZEAL 1L)
Active, not recruitingCTIS2023-508443-40-00
Start: 2020-12-18Target: 363Updated: 2026-01-09
A PHASE 3, RANDOMIZED, DOUBLE-BLIND, MULTICENTER STUDY OF DOSTARLIMAB (TSR-042) PLUS CARBOPLATIN-PACLITAXEL VERSUS PLACEBO PLUS CARBOPLATIN-PACLITAXEL IN PATIENTS WITH RECURRENT OR PRIMARY ADVANCED ENDOMETRIAL CANCER (RUBY)
Active, not recruitingCTIS2023-506551-23-00
Start: 2019-11-21Target: 225Updated: 2026-01-27
A RANDOMIZED PHASE 3 DOUBLE-BLINDED STUDY COMPARING THE EFFICACY AND SAFETY OF NIRAPARIB TO PLACEBO IN PARTICIPANTS WITH EITHER HER2-NEGATIVE BRCA-MUTATED OR TRIPLE-NEGATIVE BREAST CANCER WITH MOLECULAR DISEASE BASED ON PRESENCE OF CIRCULATING TUMOR DNA AFTER DEFINITIVE THERAPY (ZEST)
Active, not recruitingCTIS2023-504454-35-00
Start: 2021-06-22Target: 143Updated: 2024-09-30