FindTrial
Sign In

Nimorazole

DRUG3 trials

Sponsors

European Organisation for Research and Treatment of Cancer - EORTC, The Christie NHS Foundation Trust, Danish Head and Neck Cancer Group

Conditions

Gene Profile, Gene SignatureHead and Neck Squamous Cell CarcinomaHypoxiaHypoxic ModificationLocally Advanced Head and Neck HPV Negative Squamous Cell CancersRadiotherapy

Phase 3

AF CRT +/- Nimorazole in HNSCC
NCT01880359
European Organisation for Research and Treatment of Cancer - EORTCLocally Advanced Head and Neck HPV Negative Squamous Cell Cancers
Start: 2014-07-25End: 2023-01-09Target: 640Updated: 2022-05-10
NIMRAD (A Randomised Placebo-controlled Trial of Synchronous NIMorazole Versus RADiotherapy Alone in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Not Suitable for Synchronous Chemotherapy or Cetuximab)
CompletedNCT01950689
The Christie NHS Foundation TrustHead and Neck Squamous Cell Carcinoma
Start: 2014-09-11End: 2021-01-07Updated: 2021-10-19
DAHANCA 30: A Randomized Non-inferiority Trial of Hypoxia-profile Guided Hypoxic Modification of Radiotherapy of HNSCC.
NCT02661152
Danish Head and Neck Cancer GroupGene Profile, Gene Signature, Head and Neck Squamous Cell Carcinoma, Hypoxia +2
Start: 2016-09-30End: 2023-12-31Target: 1252Updated: 2021-04-13

Related Papers

Randomized Phase 3 Trial of the Hypoxia Modifier Nimorazole Added to Radiation Therapy With Benefit Assessed in Hypoxic Head and Neck Cancers Determined Using a Gene Signature (NIMRAD).
2023-12-0912 citations
Randomised phase III trial of the hypoxia modifier nimorazole added to radiotherapy with benefit assessed in hypoxic head and neck cancers determined using a gene signature (NIMRAD).
Journal of Clinical Oncology2023-06-017 citations
Hypoxic gene expression is a prognostic factor for disease free survival in a cohort of locally advanced squamous cell cancer of the uterine cervix.
2021-09-295 citations
Hypoxic gene expression is a prognostic factor for disease free survival in a cohort of locally advanced squamous cell cancer of the uterine cervix
Figshare2021-01-018 citations