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Nifurtimox

DRUG6 trials

Sponsors

Drugs for Neglected Diseases, University of Vermont, Giselle Sholler, Universidad Autónoma de Bucaramanga, University of Texas, El Paso

Conditions

Chagas DiseaseHuman African Trypanosomiasis (HAT)MedulloblastomaNeuroblastomaSleeping SicknessTrypanosoma Cruzi InfectionTrypanosomiasis, African

Phase 1

Safety Study of Nifurtimox for Relapsed or Refractory Neuroblastoma
CompletedNCT00486564
University of VermontNeuroblastoma
Start: 2006-11-30End: 2009-06-30Target: 20Updated: 2009-10-23

Phase 2

Study of Nifurtimox to Treat Refractory or Relapsed Neuroblastoma or Medulloblastoma
CompletedNCT00601003
Giselle ShollerMedulloblastoma, Neuroblastoma
Start: 2008-01-14End: 2022-10-28Updated: 2024-08-06
Pivotal Study of Fexinidazole for Human African Trypanosomiasis in Stage 2
CompletedNCT01685827
Drugs for Neglected DiseasesHuman African Trypanosomiasis (HAT), Sleeping Sickness
Start: 2012-10-31End: 2017-04-26Updated: 2018-02-20
CHICAMOCHA 3 - Equivalence of Usual Interventions for Trypanosomiasis (EQUITY)
NCT02369978
Universidad Autónoma de BucaramangaChagas Disease
Start: 2015-08-31End: 2019-02-28Target: 500Updated: 2017-07-21
New Therapies and Biomarkers for Chagas Infection
CompletedNCT03981523
University of Texas, El PasoChagas Disease, Trypanosoma Cruzi Infection
Start: 2019-12-18End: 2024-05-31Updated: 2024-07-17

Phase 3

Efficacy - Safety of Eflornithine-Nifurtimox Combination Versus Eflornithine to Treat Human African Trypanosomiasis
CompletedNCT00146627
Drugs for Neglected DiseasesTrypanosomiasis, African
End: 2008-06-30Target: 280Updated: 2016-09-29

Related Papers

Cutaneous reactions during treatment with Nifurtimox or Benznidazole among <i>Trypanosoma cruzi</i> seropositive adults without symptomatic cardiomyopathy: A safety sub analysis of a placebo‐controlled randomised trial
Tropical Medicine & International Health2025-05-192 citations
Population pharmacokinetics of benznidazole in neonates, infants and children using a new pediatric formulation
PLoS neglected tropical diseases2023-05-3110 citations
New chemotherapy regimens and biomarkers for Chagas disease: the rationale and design of the TESEO study, an open-label, randomised, prospective, phase-2 clinical trial in the Plurinational State of Bolivia
BMJ Open2021-12-0136 citations
Oral fexinidazole for stage 1 or early stage 2 African Trypanosoma brucei gambiense trypanosomiasis: a prospective, multicentre, open-label, cohort study.
2021-07-0136 citations
Nifurtimox versus benznidazole or placebo for asymptomatic Trypanosoma cruzi infection (Equivalence of Usual Interventions for Trypanosomiasis - EQUITY): study protocol for a randomised controlled trial
Trials2019-07-1533 citations
Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial.
2017-11-04169 citations
Abstract 3796: Targeting cancer stem cells using ALDH-dependent 5-nitrofuran prodrugs
Cancer Research2016-07-151 citations
Abstract C25: Targeting cancer stem cells using ALDH-dependent 5-nitrofuran pro-drugs
Molecular Cancer Therapeutics2015-12-01
Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial.
2009-06-24337 citations