Nicotinamide treatment

DRUG3 trials

Sponsors

Centre Hospitalier Universitaire, Amiens, Assistance Publique - Hôpitaux de Paris, University Hospital, Angers

Conditions

Acute Kidney InjuryDelayed Graft FunctionLeber Hereditary Optic Neuropathy (LHON)Leber's Hereditary Optic Neuropathy (LHON)Mitochondrial DiseaseMortalityNicotinamideOptic Nerve Disease

Phase 1

Pilot Study of the Efficacy of Nicotinamide (Vitamin B3) in Leber's Hereditary Optic Neuropathy

Not yet recruitingNCT07258667

University Hospital, AngersLeber Hereditary Optic Neuropathy (LHON), Leber's Hereditary Optic Neuropathy (LHON), Mitochondrial Disease +1

Start: 2026-04-30End: 2028-04-30Target: 13Updated: 2025-12-18

Phase 3

Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock?

Active, not recruitingNCT04589546

Centre Hospitalier Universitaire, AmiensAcute Kidney Injury, Mortality, Nicotinamide +1

Start: 2020-10-01End: 2025-09-30Target: 310Updated: 2025-08-24

Graft Acute Kidney Injury: Vitamin B3 to Facilitate Renal Recovery In the Early Life of a Transplant

CompletedNCT05513807

Assistance Publique - Hôpitaux de ParisDelayed Graft Function

Start: 2023-01-12End: 2024-06-18Updated: 2024-07-10