NHS-IL12

BIOLOGICAL2 trials

Sponsors

National Cancer Institute (NCI)

Conditions

Anal CancerCervical CancerColorectal CancersHPV CancersOropharyngeal CancerSmall Bowel CancersVulvar, Vaginal, Penile, Rectal Cancer

Phase 1

Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies

CompletedNCT04287868

National Cancer Institute (NCI)Anal Cancer, Cervical Cancer, HPV Cancers +2

Start: 2020-06-09End: 2026-05-14Updated: 2026-06-30

Phase 2

Phase II Trial of Combination Immunotherapy in Subjects With Advanced Small Bowel and Colorectal Cancers

CompletedNCT04491955

National Cancer Institute (NCI)Colorectal Cancers, Small Bowel Cancers

Start: 2020-09-22End: 2024-08-16Updated: 2025-04-24

Related Papers

The Quadruple Immunotherapy for Colorectal Cancer (QuICC) Trial for Mismatch Repair-Proficient Metastatic Colorectal Cancer.

2026-01-10

Novel Combination Immunotherapy and Clinical Activity in Patients With HPV-Associated Cancers

JAMA Oncology2025-02-2015 citations

New advances in cancer therapy targeting TGF-β signaling pathways

Molecular Therapy — Oncolytics2023-12-0127 citations

Phase II evaluation of combination immunotherapy with CV301, N-803, bintrafusp alfa, and M9241 in patients with advanced small bowel and colorectal cancers.

Journal of Clinical Oncology2023-01-243 citations

766 Phase I/II evaluation of the combination of entinostat, M9241 and bintrafusp alfa in patients with advanced HPV related malignancies

Regular and Young Investigator Award Abstracts2022-11-014 citations

695 Immune correlates associated with clinical benefit in patients with immune checkpoint refractory HPV-associated malignancies treated with triple combination immunotherapy

Regular and Young Investigator Award Abstracts2022-11-011 citations

Phase II evaluation of the combination of PDS0101, M9241, and bintrafusp alfa in patients with HPV 16+ malignancies.

Journal of Clinical Oncology2022-06-0111 citations

Phase II evaluation of the triple combination of PDS0101, M9241, and bintrafusp alfa in patients with HPV 16 positive malignancies.

Journal of Clinical Oncology2021-05-2020 citations

375 Expansion of HPV-16 specific T cells in patients with HPV-related cancers treated with bintrafusp alfa

Regular and Young Investigator Award Abstracts2020-11-01