Nevirapine (NVP)

DRUG4 trials

Sponsors

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Boehringer Ingelheim, University of California, San Francisco, National Institute of Allergy and Infectious Diseases (NIAID)

Conditions

Acquired Immunodeficiency SyndromeDisease Transmission, VerticalHIV InfectionHIV InfectionsMalariaVertical Human Immunodeficiency Virus Transmission

Phase 1

Very Early Intensive Treatment of Infants Living With HIV to Achieve HIV Remission

RecruitingNCT02140255

National Institute of Allergy and Infectious Diseases (NIAID)HIV Infection

Start: 2015-01-23End: 2031-12-31Target: 1120Updated: 2026-04-03

Phase 3

Trial of Three Neonatal Antiretroviral Regimens for Prevention of Intrapartum HIV Transmission

CompletedNCT00099359

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Disease Transmission, Vertical, HIV Infections, Vertical Human Immunodeficiency Virus Transmission

Start: 2004-02-29End: 2011-02-28Updated: 2012-12-04

A Study of Single Dose Nevirapine (NVP) Combined With Combivir® for the Prevention of Mother to Child Transmission (pMTCT) - Treatment Options Preservation Study (TOPS)

CompletedNCT00144183

Boehringer IngelheimAcquired Immunodeficiency Syndrome

Start: 2003-01-31End: 2007-01-31Target: 407Updated: 2013-11-04

HIV Protease Inhibitors for the Prevention of Malaria in Ugandan Children

CompletedNCT00978068

University of California, San FranciscoHIV Infections, Malaria

Start: 2009-09-30End: 2013-01-31Updated: 2018-12-28

Related Papers

ART-free HIV-1 remission in children with in-utero HIV-1 after very early ART (IMPAACT P1115): a multicentre, open-label, phase 1/2 proof-of-concept study.

2025-09-25

HIV-1 reservoir size after neonatal antiretroviral therapy and the potential to evaluate antiretroviral-therapy-free remission (IMPAACT P1115): a phase 1/2 proof-of-concept study.

2023-12-0410 citations

Infants Receiving Very Early Antiretroviral Therapy Have High CD4 Counts in the First Year of Life

Clinical Infectious Diseases2022-08-295 citations

Pharmacokinetics and safety of early nevirapine-based antiretroviral therapy for neonates at high risk for perinatal HIV infection: a phase 1/2 proof of concept study.

2020-11-2312 citations

The Mission is Remission

The Pediatric Infectious Disease Journal2018-10-222 citations

Combined evaluation of sexually transmitted infections in HIV-infected pregnant women and infant HIV transmission

PLoS ONE2018-01-0559 citations

Absence of neurocognitive disadvantage associated with paediatric HIV subtype A infection in children on antiretroviral therapy.

2017-10-018 citations

Cytomegalovirus Urinary Shedding in HIV-infected Pregnant Women and Congenital Cytomegalovirus Infection

Clinical Infectious Diseases2017-03-1629 citations

Antiretroviral agents and prevention of malaria in HIV-infected Ugandan children.

2012-11-0184 citations

Three postpartum antiretroviral regimens to prevent intrapartum HIV infection.

2012-06-01142 citations