Naloxone Hydrochloride

DRUG7 trials

Conditions

Chronic Opioid UseChronic Pain SyndromeConstipation, Impaction, and Bowel ObstructionFentanyl OverdoseFentanyl PoisoningGambling DisorderNaloxoneObesity and Obstructive Sleep apnoea

Phase 1

The Effect of Chronic Pain on Delay Discounting in Methadone Patients

TerminatedNCT04473950

University of California, San FranciscoChronic Pain Syndrome, Opioid-use Disorder

Start: 2020-01-08End: 2022-10-06Updated: 2025-03-26

Pharmacodynamic Evaluation of Intranasal Nalmefene

CompletedNCT04828005

Opiant Pharmaceuticals IncPharmacodynamic

Start: 2021-03-30End: 2022-03-14Updated: 2025-07-14

Reversal of Opioid-induced Respiratory Depression With Opioid Antagonists

RecruitingNCT05338632

Leiden University Medical CenterChronic Opioid Use, Opioid Induced Respiratory Depression

Start: 2022-06-24End: 2026-10-01Target: 24Updated: 2025-01-31

Phase 2

Effects of Intranasal Naloxone on Gambling Urges and Craving in Gambling Disorder

NCT03430180

Finnish Institute for Health and WelfareGambling Disorder, Naloxone, Opioid Antagonist +1

Start: 2018-02-22End: 2020-03-30Target: 126Updated: 2019-07-16

MORPHINE PHARMACOKINETICS AND –DYNAMICS IN HEALTHY VOLUNTEERS AND PATIENTS WITH OBESITY AND OBSTRUCTIVE SLEEP APNOEA. -AN INVESTIGATOR INITIATED, CLINICAL STUDY OF THE IMPACT OF OBESITY AND SLEEP APNOEA ON THE PHARMACOLOGY OF MORPHINE

CompletedCTIS2022-500779-29-00

Sydvestjysk SygehusObesity and Obstructive Sleep apnoea

Start: 2022-12-01End: 2025-12-16Target: 140Updated: 2025-12-16

A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone Blockade

Not yet recruitingNCT07459166

Clear Scientific, Inc.Fentanyl Overdose, Fentanyl Poisoning

Start: 2026-04-01End: 2026-10-01Target: 16Updated: 2026-03-27

Phase 3

Naloxone in Treating Constipation in Patients Who Are Receiving Opioids for Chronic Pain

NCT00020605

Dana-Farber Cancer InstituteConstipation, Impaction, and Bowel Obstruction, Unspecified Adult Solid Tumor, Protocol Specific

Start: 2000-05-31Updated: 2018-12-13

Related Papers

Reversal of Opioid-Induced Respiratory Depression in Healthy Volunteers: Comparison of Intranasal Nalmefene and Intranasal Naloxone.

2024-03-0413 citations

Treating gambling disorder with as needed administration of intranasal naloxone: a pilot study to evaluate acceptability, feasibility and outcomes