Nafamostat Mesylate

DRUG7 trials

Sponsors

Gyeongsang National University Hospital, Ensysce Biosciences, Xiaobo Yang, MD, Wonju Severance Christian Hospital, Shen Lei

Conditions

AnticoagulationBleedingCOVID-19Corona Virus InfectionCritical IllnessDialysis; ComplicationsPharmacokineticsSepsis

Phase 1

Pharmacokinetics of Oxycodone and PF614 Co-Administered with Nafamostat (PF614-MPAR-101)

CompletedNCT05090280

Ensysce BiosciencesPharmacokinetics

Start: 2021-12-01End: 2023-04-26Updated: 2024-09-24

Single Dose Study, Pharmacokinetics of Oxycodone and PF614 Co-Administered With Nafamostat (PF614-MPAR-102)

RecruitingNCT06500793

Ensysce BiosciencesPharmacokinetics

Start: 2024-11-24End: 2026-12-31Target: 30Updated: 2026-03-06

Phase 2

Clinical Efficacy of Nafamostat Mesylate for COVID-19 Pneumonia

Gyeongsang National University HospitalCorona Virus Infection, COVID-19

Start: 2020-06-10End: 2021-04-30Target: 84Updated: 2020-06-09

Efficacy and Safety of Nafamostat Mesylate for VV-ECMO Anticoagulation

Xiaobo Yang, MDAnticoagulation, Critical Illness

Start: 2022-12-20End: 2024-10-01Target: 40Updated: 2023-02-15

Phase 4

Comparison of Nafamostat and Unfractionated Heparin in RRT for Sepsis Associated AKI

Not yet recruitingNCT06375616

Start: 2024-04-30End: 2027-04-30Target: 156Updated: 2024-04-19

Unknown Phase

The Safety of Nafamostat Mesylate for Patients With High Risk Bleeding Undergoing Hemodialysis: A Pilot Study

RecruitingNCT05874674

Wonju Severance Christian HospitalBleeding, Dialysis; Complications

Start: 2023-12-01End: 2026-12-31Target: 100Updated: 2024-07-30

The Impact of Nafamostat Mesylate on the Prognosis of Patients With Sepsis-Induced Coagulopathy Undergoing Hemofiltration

Not yet recruitingNCT06994312

The First Hospital of Jilin UniversitySepsis-induced Coagulopathy (SIC)

Start: 2025-07-01End: 2028-12-01Target: 282Updated: 2025-05-29

Related Papers

Treatment effect of nafamostat mesylate in patients with COVID-19 pneumonia: study protocol for a randomized controlled trial.

2021-11-238 citations