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N-Acetyl Cysteine (NAC)

DRUG9 trials

Sponsors

Nationwide Children's Hospital, University of Miami, Johns Hopkins University, Imperial College London, Martin Lan

Conditions

Alcoholic HepatitisAnosmiaAutistic DisorderBipolar DisorderDepressionDouble J StentEmotional DysregulationInfection

Early Phase 1

NAC Trial for Anosmia
CompletedNCT02481609
University of MiamiAnosmia
Start: 2014-07-31End: 2017-12-01Updated: 2018-03-20
Brain Imaging to Understand the Role of Inflammation in N-Acetyl Cysteine (NAC) Treatment of Bipolar Depression
CompletedNCT03730064
Martin LanBipolar Disorder, Depression
Start: 2018-11-01End: 2021-03-01Updated: 2021-08-05
The MIND Study: The MGH/MIT Investigation of NAC on Dysregulation
Not yet recruitingNCT07323446
Massachusetts General HospitalEmotional Dysregulation
Start: 2026-01-01End: 2030-01-01Target: 120Updated: 2026-01-07

Phase 1

The FIGHT-RP1 Study
CompletedNCT03063021
Johns Hopkins UniversityRetinitis Pigmentosa
Start: 2017-02-15End: 2019-02-11Updated: 2022-09-19

Phase 3

N-ACetylcysteine to Reduce Infection and Mortality for Alcoholic Hepatitis
NCT03069300
Imperial College LondonAlcoholic Hepatitis, Infection
Start: 2015-10-01End: 2025-06-01Target: 42Updated: 2021-11-09
Effect of N-acetylcysteine as Adjunct Therapy on the Clinical Outcome of Neonatal Sepsis
Not yet recruitingNCT07380347
Ain Shams UniversityNeonatal Sepsis
Start: 2026-02-01End: 2026-08-01Target: 50Updated: 2026-02-02

Phase 4

Microbiological Characteristics of Biofilm on Double J Ureteral Stents After Lithotripsy.
Not yet recruitingNCT07301294
Menoufia UniversityDouble J Stent
Start: 2026-01-01End: 2026-07-01Target: 100Updated: 2025-12-24

Unknown Phase

Treatment Resistant Epilepsy and N-Acetyl Cysteine
WithdrawnNCT02054949
Nationwide Children's HospitalAutistic Disorder, Irritability, Seizures
Start: 2013-04-30End: 2015-01-31Updated: 2015-10-09
A Confirmatory Trial of Adjunctive NAC to Prevent Post Tuberculosis Lung Disease
RecruitingNCT06909799
The Aurum Institute NPCTuberculosis (TB)
Start: 2025-04-28End: 2027-12-31Target: 242Updated: 2025-04-30

Related Papers

Oral N-acetylcysteine improves cone function in retinitis pigmentosa patients in phase I trial
Journal of Clinical Investigation2019-12-05101 citations