N,N-Dimethyltryptamine

DRUG5 trials

Sponsors

Algernon Pharmaceuticals, Biomind Labs Inc., Universidade Federal do Rio Grande do Norte, University Hospital, Basel, Switzerland

Conditions

Depression, UnipolarDepressive DisorderHealthy VolunteersMajor Depressive DisorderPsychedelic ExperiencesSafety IssuesStroke

Phase 1

Single and Repeat Doses of DMT in Healthy Subjects

Active, not recruitingNCT05559931

Algernon PharmaceuticalsStroke

Start: 2023-01-13End: 2026-03-31Target: 60Updated: 2025-01-28

Clinical Study of DMT in Healthy Adults

CompletedNCT05573568

Biomind Labs Inc.Healthy Volunteers

Start: 2022-06-01End: 2022-11-14Updated: 2023-02-15

Safety and Tolerability of DMT in Healthy Adults

CompletedNCT05901012

Universidade Federal do Rio Grande do NorteHealthy Volunteers, Safety Issues

Start: 2023-04-26End: 2023-07-17Updated: 2023-10-11

Phase 2

Safety, Tolerability and Antidepressant Effects of DMT in Patients With Depression

CompletedNCT06094907

Universidade Federal do Rio Grande do NorteDepression, Unipolar, Depressive Disorder

Start: 2023-10-09End: 2024-03-30Updated: 2024-05-08

Unknown Phase

Antidepressant Response of DMT Masked With Propofol

RecruitingNCT06927076

University Hospital, Basel, SwitzerlandMajor Depressive Disorder, Psychedelic Experiences

Start: 2025-08-05End: 2029-03-01Target: 112Updated: 2026-04-02

Related Papers

Safety, tolerability and subjective effects of vaporized N,N-Dimethyltryptamine: A randomized double-blind clinical trial.

2025-06-171 citations

Safety and tolerability of NN-dimethyltryptamine (DMT) in healthy volunteers and Major Depressive Disorder (MDD) patients: A systematic review of early-phase clinical trials.

2025-06-07

Safety, Pharmacokinetics, and Pharmacodynamics of a 6‐h <i>N</i>,<i>N</i>‐Dimethyltryptamine (DMT) Infusion in Healthy Volunteers: A Randomized, Double‐Blind, Placebo‐Controlled Trial

Clinical and Translational Science2025-05-013 citations

Rapid and sustained antidepressant effects of vaporized N,N-dimethyltryptamine: a phase 2a clinical trial in treatment-resistant depression.

2025-04-227 citations

The Antidepressant Effects of Vaporized <i>N</i> , <i>N</i> -Dimethyltryptamine: An Open-Label Pilot Trial in Treatment-Resistant Depression

Psychedelic Medicine2024-08-0910 citations