N acetyl cysteine

DRUG20 trials

Sponsors

University of Chicago, University of Sao Paulo, St. Luke's Hospital and Health Network, Pennsylvania, University of Sao Paulo General Hospital, University of California, Los Angeles

Conditions

Acute Kidney InjuryAcute Organophosphorus Poisoned PatientsAcute on Chronic Liver Failure(ACLF)AnosmiaAnti Oxidative StressAntioxidantAutism Spectrum DisorderCancer Patients

Early Phase 1

N-Acetyl Cysteine Protects Pulpal Stem Cells in Endodontic Revascularization

TerminatedNCT03451435

University of California, Los AngelesEndodontic Disease

Start: 2018-06-15End: 2019-04-01Updated: 2026-01-21

The Role of N-acetylcysteine as a Novel Adjuvant Treatment in Acute Organophosphorus Pesticide Poisoning

CompletedNCT05927259

Ain Shams UniversityAcute Organophosphorus Poisoned Patients

Start: 2022-01-01End: 2023-06-01Updated: 2023-07-03

Phase 1

Comparison of the Outcome of Treatment With Silymarin or N-Aceylcysteine in Patients Taking Anti-Tuberculous Drugs for Tuberculosis at a Tertiary Care Hospital , Karachi

Not yet recruitingNCT07058090

Liaquat National Hospital & Medical CollegeDrug Induced Liver Injury, Tuberculosis (TB)

Start: 2025-07-31End: 2026-05-31Target: 410Updated: 2025-07-10

Phase 2

N-Acetyl Cysteine Plus Behavioral Therapy for Nicotine Dependent Pathological Gamblers

CompletedNCT00967005

University of ChicagoGambling, Tobacco Use Disorder

Start: 2009-09-30End: 2014-08-31Updated: 2023-03-21

FDOPA PET and Nutritional Support in Parkinson's Disease

Active, not recruitingNCT04459052

Thomas Jefferson UniversityIdiopathic Parkinson Disease, Parkinson Disease

Start: 2020-04-30End: 2027-01-08Target: 50Updated: 2025-07-29

Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Trial

RecruitingNCT05664789

Stanford UniversityAutism Spectrum Disorder

Start: 2023-04-26End: 2028-07-31Target: 144Updated: 2026-01-20

Efficacy of N-acetylcysteine to Prevent Anti-tuberculosis Drug-induced Liver Injury: A Randomized Controlled Trial

Mahidol UniversityDrug Induced Liver Injury, Hepatitis, Tuberculosis

Start: 2022-09-09End: 2023-05-31Target: 82Updated: 2023-02-22

Evaluation of the Effect of N-acetylcysteine in Preventing Cisplatin-Induced Toxicities in Cancer Patients

RecruitingNCT06297369

Ain Shams UniversityCancer Patients, Cisplatin Adverse Reaction, Cisplatin Induced Peripheral Neuropathy +2

Start: 2024-02-01End: 2025-08-01Target: 60Updated: 2024-03-07

Phase 3

NAC for Head Trauma-induced Anosmia

TerminatedNCT03680911

University of MiamiAnosmia, Head Trauma

Start: 2018-10-12End: 2020-01-07Updated: 2021-02-04

N-acetyl Cysteine for the Prevention of Oral Mucositis After Autologous Hematopoietic Cell Transplantation.

moshe yeshurunMucositis, Transplant-Related Disorder

Start: 2021-04-01End: 2023-03-31Target: 116Updated: 2021-02-16

Evaluation of the Role of N Acetyl Cysteine and Vitamin D in Improving Outcomes After Corrosive Ingestion

Active, not recruitingNCT07229456

Ain Shams UniversityCorrosive Injury

Start: 2024-10-01End: 2025-12-01Updated: 2025-11-17

Phase 4

N Acetyl Cysteine for Cystinosis Patients

CompletedNCT01614431

University of Sao PauloCystinosis, Renal Disease

Start: 2011-03-31End: 2012-05-31Updated: 2012-06-20

Prevention of Acute Kidney Injury by N-Acetylcystein in Patients Undergone Cardiac Valve Replacement

University of Sao Paulo General HospitalAcute Kidney Injury, Cardiac Valve Disease, Oxygen Radical Damage +2

Start: 2018-03-15End: 2020-03-15Target: 154Updated: 2018-03-05

Efficacy of Intravenous N-Acetylcysteine in Preventing Linezolid-Induced Thrombocytopenia in Critically Ill Patients

CompletedNCT05944458

Helwan UniversityAntioxidant, Critical Illness, ICU +2

Start: 2023-08-01End: 2025-06-01Updated: 2025-07-14

Gene-guided N-acetyl Cysteine for Prophylaxis of Anti-tuberculous Drug- Induced Hepatitis

RecruitingNCT06484530

Mahidol UniversityEthambutol Toxicity, Isoniazid Toxicity, N-Acetylcysteine +6

Start: 2024-03-12End: 2024-09-18Target: 116Updated: 2024-07-03

N-Acetyl Cysteine Effect on Liver Function After Mitral Valve Replacement

CompletedNCT06486805

Kasr El Aini HospitalLiver Dysfunction, Oxidative Stress

Start: 2024-06-30End: 2024-12-30Updated: 2025-08-29

Unknown Phase

Use of NAC in Alleviation of Hangover Symptoms

CompletedNCT02541422

St. Luke's Hospital and Health Network, PennsylvaniaHangover Symptoms, NAC

Start: 2015-08-31End: 2015-12-31Updated: 2018-05-30

Intravenous NAC Use in ACLF Patients

Aga Khan UniversityAcute on Chronic Liver Failure(ACLF)

Start: 2021-11-01End: 2023-03-01Target: 100Updated: 2021-10-22

Comparison of the Effects of N-acetylcysteine, Calcium Hydroxide, and Double Antibiotic Paste

CompletedNCT07340944

Ataturk UniversityChronic Apical Periodontitis

Start: 2022-09-10End: 2024-05-15Updated: 2026-01-15

Comparing N-Acetylcysteine (NAC) Versus Alpha-Lipoic Acid (ALA) as Adjuncts for Postoperative Pain Management After Laparoscopic Appendectomy

Not yet recruitingNCT07360379

Ain Shams UniversityAnti Oxidative Stress, Laparoscopic Appendectomy, Pain Management

Start: 2025-12-28End: 2026-05-01Target: 180Updated: 2026-01-22

Related Papers

N-acetylcysteine reduces incidence and duration of linezolid-associated thrombocytopenia in critically ill patients: A randomized controlled trial.

2026-01-21

A Randomized, Placebo-Controlled Trial of<i>N</i>-Acetylcysteine Plus Imaginal Desensitization for Nicotine-Dependent Pathological Gamblers

The Journal of Clinical Psychiatry2013-11-20134 citations