Multi-peptide CMV-Modified Vaccinia Ankara Vaccine

BIOLOGICAL9 trials

Sponsors

City of Hope Medical Center

Conditions

Accelerated Phase CML, BCR-ABL1 PositiveAccelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 PositiveAccelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 PositiveAcute Lymphoblastic LeukemiaAcute Lymphoblastic Leukemia in RemissionAcute Myeloid LeukemiaAcute Myeloid Leukemia in RemissionB-Cell Non-Hodgkin Lymphoma

Early Phase 1

Allogeneic CMV-Specific CD19-CAR T Cells Plus CMV-MVA Triplex Vaccine After Matched Related Donor Hematopoietic Cell Transplant for the Treatment of Patients With High-Risk Acute Lymphoblastic Leukemia

RecruitingNCT06735690

City of Hope Medical CenterAcute Lymphoblastic Leukemia

Start: 2025-06-09End: 2029-03-07Target: 15Updated: 2025-11-12

Phase 1

Multi-antigen CMV-Modified Vaccinia Ankara Vaccine in Treating Pediatric Patients With Positive Cytomegalovirus Undergoing Donor Stem Cell Transplant

RecruitingNCT03354728

City of Hope Medical CenterCytomegaloviral Infection, Hematopoietic Cell Transplant Recipient

Start: 2018-05-11End: 2026-12-11Target: 80Updated: 2025-10-06

CMV-MVA Triplex Vaccination of Stem Cell Donors in Preventing CMV Viremia in Participants With Allogeneic Transplant

Active, not recruitingNCT03560752

City of Hope Medical CenterAccelerated Phase CML, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia in Remission +11

Start: 2018-08-20End: 2026-07-29Updated: 2025-12-10

Genetically Modified T-cells (CMV-Specific CD19-CAR T-cells) Plus a Vaccine (CMV-MVA Triplex) Following Stem Cell Transplantation for the Treatment of Intermediate or High Grade B-cell Non-Hodgkin Lymphoma

RecruitingNCT05432635

City of Hope Medical CenterB-Cell Non-Hodgkin Lymphoma, Diffuse Large B-Cell Lymphoma, Mantle Cell Lymphoma +5

Start: 2023-08-01End: 2028-12-30Target: 15Updated: 2026-02-23

Genetically Modified T-cells (CMV-Specific CD19-CAR T-cells) Plus a Vaccine (CMV-MVA Triplex) for the Treatment of Intermediate or High Grade B-Cell Non-Hodgkin Lymphoma

RecruitingNCT05801913

City of Hope Medical CenterHigh Grade B-Cell Non-Hodgkin's Lymphoma, Intermediate Grade B-Cell Non-Hodgkin's Lymphoma, Recurrent B-Cell Non-Hodgkin Lymphoma +1

Start: 2023-09-29End: 2028-12-30Target: 15Updated: 2026-03-05

A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant

RecruitingNCT07020533

City of Hope Medical CenterAccelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia +9

Start: 2026-05-08End: 2030-02-14Target: 46Updated: 2026-03-27

Phase 2

Multi-antigen CMV-MVA Triplex Vaccine in Reducing CMV Complications in Patients Previously Infected With CMV and Undergoing Donor Hematopoietic Cell Transplant

Active, not recruitingNCT02506933

City of Hope Medical CenterAccelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia in Remission +10

Start: 2015-11-05End: 2026-06-09Updated: 2025-08-22

Triplex Vaccine in Preventing CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplantation

Active, not recruitingNCT04060277

City of Hope Medical CenterAccelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia +9

Start: 2019-11-27End: 2030-04-07Updated: 2025-11-14

CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

RecruitingNCT06059391

City of Hope Medical CenterAcute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Chronic Lymphocytic Leukemia +7

Start: 2024-07-12End: 2029-01-01Target: 216Updated: 2026-03-10

Related Papers

Hematopoietic stem cell donor vaccination with cytomegalovirus triplex augments frequencies of functional and durable cytomegalovirus‐specific T cells in the recipient: A novel strategy to limit antiviral prophylaxis

American Journal of Hematology2023-01-039 citations

Vaccination of Hematopoietic Stem Cell (HCT) Donors with Triplex, a Novel Cytomegalovirus Vaccine: Safety, Feasibility and Adoptive Transfer of Protective CMV-Specific T Cells in HCT Recipients

Blood2020-11-04

Poxvirus Vectored Cytomegalovirus Vaccine to Prevent Cytomegalovirus Viremia in Transplant Recipients: A Phase 2, Randomized Clinical Trial.

2020-02-1165 citations

MVA vaccine encoding CMV antigens safely induces durable expansion of CMV-specific T cells in healthy adults

Blood2016-10-1981 citations