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Multi-cancer early detection test

DEVICE9 trials

Sponsors

GRAIL, Inc., Shanghai Zhongshan Hospital, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Zhujiang Hospital, Fudan University

Conditions

CancerEarly Detection of CancerGynecologic CancerHepatobiliary MalignanciesNeoplasms

Unknown Phase

Assessment of the Implementation of an Investigational Multi-Cancer Early Detection Test Into Clinical Practice
CompletedNCT04241796
GRAIL, Inc.Cancer
Start: 2019-12-12End: 2022-01-05Updated: 2022-10-25
Pan-canceR Early DetectIon projeCT (PREDICT)
NCT04817306
Shanghai Zhongshan HospitalCancer
Start: 2021-03-29End: 2023-03-31Target: 14026Updated: 2021-03-30
The Unintrusive Detection of EaRly-stage Cancers
CompletedNCT04820868
Shanghai Zhongshan HospitalCancer
Start: 2021-04-23End: 2022-04-30Updated: 2023-03-16
Pan-canceR Early-Stage deteCtion by lIquid Biopsy tEchNique projecT
NCT04822792
Cancer Institute and Hospital, Chinese Academy of Medical SciencesCancer
Start: 2021-03-23End: 2023-06-30Target: 11879Updated: 2021-06-02
AssesSment of Early-deteCtion basEd oN liquiD Biopsy in Hepatobiliary Cancer Malignancies
CompletedNCT04835675
Zhujiang HospitalHepatobiliary Malignancies
Start: 2021-03-12End: 2022-06-30Updated: 2023-03-02
PERformance of Multi-Cancer Early-detectIon Based on Various Biomarkers in fEmale Cancers, PERCEIVE-I
NCT04903665
Fudan UniversityGynecologic Cancer
Start: 2021-02-11End: 2022-12-31Updated: 2022-07-28
A Proof of Concept Study of Pan-cancer Early Detection by Liquid Biopsy
CompletedNCT04972201
Cancer Institute and Hospital, Chinese Academy of Medical SciencesCancer
Start: 2021-06-01End: 2022-06-30Updated: 2024-12-27
PATHFINDER 2: A Multi-Cancer Early Detection Study
Active, not recruitingNCT05155605
GRAIL, Inc.Cancer, Early Detection of Cancer
Start: 2021-12-08End: 2028-04-30Updated: 2026-05-14
PRediction Of Five Usual Tumors Using Blood Test for Risk Assessment and Early Detection
NCT05874648
Sixth Affiliated Hospital, Sun Yat-sen UniversityCancer, Neoplasms
Start: 2023-07-07End: 2024-10-31Target: 3830Updated: 2023-05-25

Related Papers

Safety and performance results from PATHFINDER 2, a registrational study of a multi-cancer early detection (MCED) test in an intended-use population.
Journal of Clinical Oncology2026-06-03
Abstract C145: Baseline participant characteristics from PATHFINDER 2, a prospective interventional study of a multi-cancer early detection test in a population setting
Cancer Epidemiology Biomarkers & Prevention2025-09-18
Prognostic significance of preoperational circulating tumor DNA detection in early-stage NSCLC using a tissue-free blood test.
Journal of Clinical Oncology2025-05-28
Development and clinical validation of a cell-free DNA methylation sequencing test for multi-cancer early detection.
Journal of Clinical Oncology2025-05-28
Abstract 1945: High-sensitive gastrointestinal cancers early detection by cell-free DNA targeted methylation sequencing with an innovative modeling approach
Cancer Research2025-04-21
Psychosocial impact associated with a multicancer early detection test (PATHFINDER): a prospective, multicentre, cohort study.
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A Targeted Methylation–Based Multicancer Early Detection Blood Test Preferentially Detects High-Grade Prostate Cancer While Minimizing Overdiagnosis of Indolent Disease
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Impact of cancer screening results on patient-reported outcomes (PRO) and behavioral intentions.
Journal of Clinical Oncology2024-06-01
Multi-cancer early detection (MCED) test performance in cancer survivors.
Journal of Clinical Oncology2024-05-29
Abstract 4784: PATHFINDER 2: A prospective study to evaluate safety and performance of a multi-cancer early detection test in a population setting
Cancer Research2024-03-223 citations
Abstract 1264: A targeted methylation-based multi-cancer early detection blood test preferentially detects high-grade prostate cancer and minimizes overdiagnosis
Cancer Research2024-03-22
Multi-Cancer Early Detection Test Is Sensitive and Accurate in Detecting Shared DNA Methylation Signal in a Variety of Lymphoid and Plasma Cell Neoplasms
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Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study.
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S352 Detection of Gastrointestinal Cancer in Individuals Without Clinical Suspicion of Cancer Using a Multi-Cancer Early Detection Test in the PATHFINDER Study
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DNA methylation patterns between tissue and blood samples in ovarian cancer.
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Krebsscreening
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Unintrusive multi-cancer detection by circulating cell-free DNA methylation sequencing (THUNDER): development and independent validation studies.
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Cell-Free DNA–Based Multi-Cancer Early Detection Test in an Asymptomatic Screening Population (NHS-Galleri): Design of a Pragmatic, Prospective Randomised Controlled Trial
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