MRI-guided laser ablation

DEVICE2 trials

Sponsors

Washington University School of Medicine

Conditions

Anaplastic AstrocytomaAstrocytomaGlioblastomaGliomaMalignant GliomaMixed GliomaMixed OligoastrocytomaOligodendroglioma

Phase 1

MK-3475 in Combination With MRI-guided Laser Ablation in Recurrent Malignant Gliomas

CompletedNCT02311582

Washington University School of MedicineMalignant Glioma

Start: 2015-08-05End: 2024-04-15Updated: 2025-05-29

Phase 2

Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors

TerminatedNCT02372409

Washington University School of MedicineAnaplastic Astrocytoma, Astrocytoma, Glioblastoma +6

Start: 2015-08-14End: 2023-03-23Updated: 2024-11-01

Related Papers

Laser interstitial thermal therapy and adjuvant pembrolizumab in recurrent high-grade astrocytoma: a Phase 1/randomized Phase 2b trial

Nature Communications2026-02-26

CTIM-11. LASER INTERSTITIAL THERMAL THERAPY PLUS PEMBROLIZUMAB PROLONGS SURVIVAL AND ELICITS ROBUST ANTI-TUMOR IMMUNITY IN RECURRENT, REFRACTORY HIGH-GRADE ASTROCYTOMA: A PHASE 1/RANDOMIZED PHASE 2B TRIAL

Neuro-Oncology2025-11-01

CTIM-26. PHASE I/II STUDY OF THE COMBINATION OF PEMBROLIZUMAB (MK-3475) AND LASER INTERSTITIAL THERMAL THERAPY (LITT) IN RECURRENT GLIOBLASTOMA

Neuro-Oncology2021-11-025 citations