MLN9708
Sponsors
National Cancer Institute (NCI), Ehab L Atallah, Nantes University Hospital, M.D. Anderson Cancer Center, Jason Valent
Conditions
Acute LeukemiaAcute Myeloid LeukemiaAdvanced CancersBreast CancerChronic LeukemiaKahler DiseaseLymphomaLymphoma, T-Cell
Phase 1
Vincristine, Doxorubicin, And Dexamethasone + Ixazomib in Acute Lymphoblastic Leukemia (ALL), Lymphoblastic Lymphoma Or Mixed Phenotype Acute Leukemia
TerminatedNCT01887587
Start: 2013-06-30End: 2016-02-29Updated: 2020-01-22
MLN9708 and Vorinostat in Patients With Advanced p53 Mutant Malignancies
CompletedNCT02042989
Start: 2014-06-27End: 2020-01-22Updated: 2022-07-11
MLN9708 (Ixazomib) in Combination With Panobinostat and Dexamethasone in Multiple Myeloma
CompletedNCT02057640
Start: 2014-05-22End: 2018-05-15Updated: 2019-12-11
Phase I Study of the Combination of MLN9708 and Fulvestrant
TerminatedNCT02384746
Start: 2015-06-02End: 2018-06-10Updated: 2019-04-29
Study of Bendamustine and IXAZOMIB (MLN9708) Plus Dexamethasone in Relapsed/Refractory Multiple Myeloma
CompletedNCT02477215
Start: 2015-10-09End: 2020-09-17Updated: 2020-10-22
MLN 9708 in Induction and Consolidation for Adults With AML >= 60 Years of Age
CompletedNCT02582359
Start: 2016-01-31End: 2022-04-30Updated: 2022-08-24
Dose Escalation Study of Nelfinavir Plus MLN9708 in Patients With Advanced Solid Tumors or Lymphoma
WithdrawnNCT03422874
Start: 2016-08-31End: 2017-08-04Updated: 2018-02-06
Phase 2
MLN9708 and Dexamethasone for High-Risk Smoldering Multiple Myeloma
WithdrawnNCT01660997
Start: 2012-07-30End: 2014-03-11Updated: 2019-12-16
Safety and Efficacy Study of a Triplet Combination of MLN9708, Lenalidomide and Dexamethasone in the Initial Management of Multiple Myeloma (IFM2013-06)
CompletedNCT01936532
Start: 2014-11-12End: 2020-06-04Updated: 2026-09-14
Open-label, Phase II Study of MLN9708 in Patients With Relapsed/Refractory Cutaneous and Peripheral T-cell Lymphomas
CompletedNCT02158975
Start: 2014-09-30End: 2016-11-30Updated: 2017-11-13
Determining the Feasibility of MLN9708 as Maintenance After Allogeneic Stem Cell Transplant for Multiple Myeloma
CompletedNCT02168101
Start: 2014-09-30End: 2019-02-01Updated: 2020-02-27
Nonmyeloablative Haploidentical Transplant Followed by MLN9708
CompletedNCT02169791
Start: 2014-07-15End: 2020-07-28Updated: 2021-09-02
STUDY THAT COMPARE 3 ARM: MLN9708 DEXAMETHASONE, MLN9708 CYCLOPHOSPHAMIDE AND DEXAMETHASONE, MLN9708 THALIDOMIDE AND DEXAMETHASONE FOLLOWED BY MAINTENANCE WITH MLN9708 IN NEWLY DIAGNOSED ELDERLY MULTIPLE MYELOMA PATIENTS
CompletedNCT02586038
Start: 2015-10-31End: 2023-12-31Target: 175Updated: 2024-05-08
Pomalidomide, Ixazomib, and Dexamethasone With or Without Intensification by Cyclophosphamide in Relapsed or Refractory Multiple Myeloma
CompletedNCT03731832
Start: 2018-09-20End: 2024-04-22Updated: 2025-09-30