MK-3543
Sponsors
Merck Sharp & Dohme LLC
Conditions
Essential Thrombocythemia patients who have an inadequate response to or are intolerant of hydroxyureaEssential thrombocythemiaMyeloproliferative Neoplasms (Essential ThrombocythemiaPolycythemia Vera and Myelofibrosis)
Phase 3
A Phase 3, Randomized, Open-label, Active-Comparator-Controlled Clinical Study to Evaluate the Safety and Efficacy of Bomedemstat (MK-3543/IMG-7289) versus Best Available Therapy (BAT) in Participants With Essential Thrombocythemia who have an Inadequate Response to or are Intolerant of Hydroxyurea
RecruitingCTIS2023-504865-21-00
Start: 2024-04-15Target: 155Updated: 2025-10-28
A Multicenter, Open-Label, Extension Study Evaluating the Safety and Efficacy of Bomedemstat for the Treatment of Participants Enrolled in a Prior Bomedemstat Clinical Study
RecruitingCTIS2023-506996-89-00
Start: 2024-06-13Target: 25Updated: 2026-01-21
A Phase 3, Randomized, Double-blind, Active-Comparator-Controlled Clinical Study to Evaluate the Efficacy and Safety of Bomedemstat (MK-3543) versus Hydroxyurea in Cytoreductive Therapy Naïve Essential Thrombocythemia Participants
RecruitingCTIS2023-505232-36-00
Start: 2024-11-15Target: 153Updated: 2025-10-28