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MK-3475A

DRUG6 trials

Sponsors

Merck Sharp & Dohme LLC

Conditions

Advanced or Metastatic Nonsquamous NSCLCCompletely resected Stage IIA-IIIB (N2) KRAS G12C mutated NSCLCFirst-line treatment of participants with metastatic nonsmall cell lung cancerMelanomaNon-small Cell Lung CancerNon-small cell lung cancerParticipants with KRAS G12C-MutantRelapsed or Refractory Classical Hodgkin’s Lymphoma (rrcHL) or Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma (rrPMBCL)

Phase 2

Phase 3

A Phase 3 Randomized, Open-label Clinical Study to Evaluate the Pharmacokinetics and Safety of Subcutaneous Pembrolizumab Coformulated With Hyaluronidase (MK-3475A) Versus Intravenous Pembrolizumab, Administered With Chemotherapy, in the First-line Treatment of Participants With Metastatic Non-small Cell Lung Cancer
Active, not recruitingCTIS2022-501506-36-00
Merck Sharp & Dohme LLCFirst-line treatment of participants with metastatic nonsmall cell lung cancer
Start: 2023-04-11Target: 100Updated: 2025-08-20
A Phase 3, Randomized, Open-label, Multicenter Clinical Study to Evaluate the Safety and Efficacy of MK-1084 in Combination With Subcutaneous Pembrolizumab and Berahyaluronidase alfa (MK-3475A) Versus MK-3475A in Combination With Pemetrexed/Platinum (Carboplatin or Cisplatin) Chemotherapy as First-line Treatment of Participants With KRAS G12C-Mutant, Advanced or Metastatic Nonsquamous NSCLC (KANDLELIT-007)
RecruitingCTIS2024-514500-14-00
Merck Sharp & Dohme LLCAdvanced or Metastatic Nonsquamous NSCLC, Participants with KRAS G12C-Mutant
Start: 2025-12-15Target: 206Updated: 2026-01-19
MK-3475A±Calderasib (MK-1084) in Completely Resected Stage IIA-IIIB (N2) KRAS G12Cm NSCLC (MK-1084-013)
RecruitingNCT07431827
Merck Sharp & Dohme LLCNon-small Cell Lung Cancer
Start: 2026-03-18End: 2039-10-26Target: 400Updated: 2026-05-11
A Phase 3, Randomized, Double-blind Study of Adjuvant MK-1084 Plus Subcutaneous Pembrolizumab and Berahyaluronidase Alfa (MK-3475A) versus Adjuvant Placebo Plus MK-3475A in Participants with Completely Resected Stage IIA-IIIB (N2), KRAS G12C-mutant Non-small Cell Lung Cancer following Receipt of Either Neoadjuvant Pembrolizumab Plus Chemotherapy or Adjuvant Chemotherapy (KANDLELIT-013)
Not yet recruitingCTIS2024-517337-41-00
Merck Sharp & Dohme LLCCompletely resected Stage IIA-IIIB (N2) KRAS G12C mutated NSCLC
Target: 36Updated: 2026-04-20