MK-1308A
Sponsors
Merck Sharp & Dohme LLC
Conditions
Advanced melanoma with brain metastasesClear cell renal cancerHepatocellular carcinomaPD-1 refractory melanomaPD-1 refractory or PD-1 naiveParticipants with Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal CancerParticipants with extensive-stage small cell lung cancerRenal cell carcinoma
Phase 1
A Phase 1b/2 Study of Immune and Targeted Combination Therapies in Participants with RCC (KEYMAKER-U03): Substudy 03A in First Line Metastatic Participants
RecruitingCTIS2023-506838-68-00
Start: 2020-12-10Target: 62Updated: 2025-11-07
A Phase 1/2 Open-Label Rolling-Arm Umbrella Platform Design of Investigational Agents With or Without Pembrolizumab or Pembrolizumab Alone in Participants With Melanoma (KEYMAKER-U02): Substudy 02D
CompletedCTIS2023-506315-17-00
Start: 2021-06-25End: 2025-10-17Target: 49Updated: 2025-11-24
A Phase 1/2 Open-Label Rolling-Arm Umbrella Platform Design of Investigational Agents With or Without Pembrolizumab or Pembrolizuma Alone in Participants With Melanoma (KEYMAKER-U02): Substudy 02B
RecruitingCTIS2023-506313-21-00
Start: 2020-08-03Target: 71Updated: 2025-11-21
A Phase 1b/2 Study of Immune and Targeted Combination Therapies in Participants with RCC (KEYMAKER-U03): substudy 03B in Second-Line Metastatic Participants
Active, not recruitingCTIS2023-506839-15-00
Start: 2020-12-21Target: 68Updated: 2025-11-26
A Phase 1b/2 Study to Evaluate the Efficacy and Safety of Investigational Agents as Monotherapy or in Combination With Pembrolizumab for the Treatment of Participants With PD-1/L1-refractory Extensive-Stage Small Cell Lung Cancer in Need of Second-Line Therapy (KEYNOTE-B98)
Active, not recruitingCTIS2023-507687-38-00
Start: 2021-08-23Target: 59Updated: 2026-01-09
Phase 2
A Phase 2, Multicenter, Clinical Study to Evaluate the Safety and Efficacy of MK-1308A (Coformulated MK-1308/MK-3475) in Combination with Lenvatinib (E7080/MK-7902) in First-line Therapy of Participants with Advanced Hepatocellular Carcinoma
CompletedCTIS2023-505698-34-00
Start: 2021-07-13End: 2025-07-22Target: 26Updated: 2025-03-05
A Phase 2, Multicenter, Multi Arm, Study to Evaluate MK-1308A (Coformulated quavonlimab (MK-1308)/pembrolizumab) Versus Other Treatments in Participants with Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer: (MK-1308A-008)
Active, not recruitingCTIS2022-502100-70-00
Start: 2021-06-23Target: 244Updated: 2026-01-27