Mitoxantrone liposome

DRUG4 trials

Sponsors

Hui Zeng, The First Affiliated Hospital of Soochow University, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing Tongren Hospital

Conditions

Acute LeukemiaAdolescentsChildrenExtranodal NK T Cell LymphomaHemophagocytic Lymphohistiocytosis (HLH)Relapsed or Refractory Acute Myeloid LeukemiaSolid Tumors

Phase 1

Clinical Study of Mitoxantrone Hydrochloride Liposome Injection in Subjects With Acute Myeloid Leukemia

RecruitingNCT05522192

Hui ZengRelapsed or Refractory Acute Myeloid Leukemia

Start: 2022-07-21End: 2026-05-31Target: 70Updated: 2022-08-30

Combination of Mitoxantrone Liposome and Etoposide, Dexamethasone, Pegaspargase and Golidocitinib (MEPL-G) in the Treatment of NK/T-cell Lymphoma Associated Hemophagocytic Lymphohistiocytosis (NKTCL-HLH)

RecruitingNCT07525466

Beijing Tongren HospitalExtranodal NK T Cell Lymphoma, Hemophagocytic Lymphohistiocytosis (HLH)

Start: 2026-04-01End: 2028-09-30Target: 25Updated: 2026-04-13

Phase 2

M-PTCy vs BuCy in Haploidentical HSCT for Acute Leukemia

The First Affiliated Hospital of Soochow UniversityAcute Leukemia

Start: 2023-01-01End: 2025-01-31Target: 60Updated: 2023-02-22

A Prospective, Single-arm Clinical Study of Liposomal Mitoxantrone Combination Regimen in the Treatment of Relapsed and Refractory Solid Tumors in Children, Adolescents and Young Adults

RecruitingNCT06761417

Cancer Institute and Hospital, Chinese Academy of Medical SciencesAdolescents, Children, Solid Tumors

Start: 2025-01-24End: 2028-02-01Target: 49Updated: 2026-05-07