Mitotane
Sponsors
Uppsala University Hospital, Assistance Publique Hopitaux De Paris, Universitaetsklinikum Wuerzburg AöR, Unicancer, Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia, Collaborative Group for Adrenocortical Carcinoma Treatment, Children's Oncology Group
Conditions
Adrenal CancerAdrenal Cortical CancerAdrenal Cortical CarcinomaAdrenocortical CarcinomaAdrenocortical carcinomaCarcinoma, Adrenal CorticalENSAT Stage I Adrenal Cortex CarcinomaENSAT Stage II Adrenal Cortex Carcinoma
Phase 1
Phase 2
IMC-A12 With Mitotane vs Mitotane Alone in Recurrent, Metastatic, or Primary ACC That Cannot Be Removed by Surgery
TerminatedNCT00778817
Start: 2008-12-31End: 2014-03-31Updated: 2014-04-29
A Phase II Study to Evaluate the Efficacy and Safety of Pembrolizumab in Combination With Mitotane in Patients With Advanced Adrenocortical Carcinoma
TerminatedNCT05634577
Start: 2023-03-23End: 2024-07-10Updated: 2025-06-19
Pan-MSI-ACSE: Dostarlimab as first-line treatment for patients with dMMR/MSI (non-colorectal/non-endometrial) locally advanced or metastatic cancer: a randomized phase 2 trial (Cohort Pan-MSI-ACSE) with crossover in the standard arm at progression
RecruitingCTIS2023-505298-34-00
Start: 2024-07-18Target: 120Updated: 2025-03-04
PROSPECTIVE, PHASE II STUDY TO EVALUATE THE EFFICACY OF ADDITION OF PROGESTERONE TO STANDARD CHEMOTHERAPY ACCORDING TO EDP SCHEME PLUS MITOTANE IN PATIENTS WITH ADVANCED ADRENAL CORTICAL CARCINOMA - PESETA TRIAL
Not yet recruitingCTIS2024-520160-34-00
Target: 80Updated: 2025-06-19
Phase II Study of PD-1 Inhibitor Combined With Apatinib and Mitotane in the Treatment of Advanced Adrenal Cortical Carcinoma
RecruitingNCT06831175
Start: 2025-03-15End: 2031-12-31Target: 28Updated: 2025-06-03
Phase 3
Trial in Locally Advanced and Metastatic Adrenocortical Carcinoma Treatment (FIRM-ACT)
CompletedNCT00094497
Start: 2004-06-30End: 2010-12-31Updated: 2016-09-21
Cisplatin-Based Chemotherapy and/or Surgery in Treating Young Patients With Adrenocortical Tumor
CompletedNCT00304070
Start: 2007-05-03End: 2023-06-30Updated: 2024-02-28
Efficacy of Adjuvant Mitotane Treatment (ADIUVO)
NCT00777244
Start: 2008-04-30End: 2020-12-31Target: 200Updated: 2017-05-08
Mitotane With or Without Cisplatin and Etoposide After Surgery in Treating Patients With Stage I-III Adrenocortical Cancer With High Risk of Recurrence
RecruitingNCT03583710
Start: 2018-08-20End: 2029-01-01Target: 240Updated: 2026-01-30
Adjuvant mitotane vs. mitotane with cisplatin/etoposide after primary surgical resection of localised adrenocortical carcinoma with high risk of recurrence (ADIUVO-2 Trial): A pragmatic, randomised, low-intervention phase III, clinical trial with an observational arm.
RecruitingCTIS2022-500013-32-01
Start: 2024-07-05Target: 120Updated: 2025-09-16