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MF59

BIOLOGICAL15 trials

Sponsors

National Institute of Allergy and Infectious Diseases (NIAID), Novartis Pharmaceuticals, Biomedical Advanced Research and Development Authority, Ab&B Bio-tech Co., Ltd.JS

Conditions

A/Vietnam/H5N1 Influenza VirusAlzheimer's DiseaseAvian InfluenzaHIV InfectionsHIV SeronegativityInfluenzaInfluenza ImmunisationInfluenza Vaccine

Phase 1

Active Immunization of HIV-Infected Pregnant Women: A Phase I Study of Safety and Immunogenicity of a rgp120/HIV-1 Vaccine (NOTE: Some Patients Receive Placebo)
WithdrawnNCT00001046
National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections, HIV Seronegativity, Pregnancy
Updated: 2021-11-01
A Phase I, Randomized, Double-Blind, Placebo-Controlled, Clinical Trial to Compare the Safety and Immunogenicity of Recombinant Envelope Protein rgp120/HIV-1SF2 (BIOCINE) Combined With Seven Adjuvants in Healthy HIV-1 Uninfected Individuals
CompletedNCT00001042
National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections
End: 1996-03-31Updated: 2021-11-04
A Phase I Comparative Blinded Trial of Several HIV-1 Derived Immunogens in Infected Individuals With >= 500 CD4 Cells/mm3
CompletedNCT00000779
National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections
End: 1996-09-30Target: 130Updated: 2021-11-04
A Study to Evaluate the Safety and Effectiveness of HIV-1 LAI gp120 (an HIV Vaccine) Given With or Without HIV-1 MN rgp120 (Another HIV Vaccine) to HIV-Negative Volunteers
CompletedNCT00000868
National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections, HIV Seronegativity
End: 2000-05-31Target: 27Updated: 2021-10-28
A Randomized, Placebo-Controlled, Double-Blinded Phase I Safety and Immunogenicity Trial of Recombinant Envelope Protein, HIV-1 SF-2 rgp120 (BIOCINE), Combined With MF59 in HIV-1 Uninfected Adult Volunteers
CompletedNCT00000832
National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections
End: 1998-01-31Updated: 2021-11-04
H5N8 Mix and Match With or Without AS03 or MF59 in Healthy Adults: Immunology
CompletedNCT03014310
National Institute of Allergy and Infectious Diseases (NIAID)Avian Influenza
Start: 2017-01-09End: 2018-12-19Updated: 2024-09-23
Clinical Trial of Subunit Influenza Vaccine (Adjuvant) in Chinese Population Aged 65 Years and Older
Active, not recruitingNCT07421050
Ab&B Bio-tech Co., Ltd.JSInfluenza, Influenza Vaccine
Start: 2025-11-13End: 2026-12-13Updated: 2026-02-19
Clinical Trial of Quadrivalent Subunit Influenza Vaccine (Adjuvant) in Chinese Population Aged 65 Years and Older
Active, not recruitingNCT07421037
Ab&B Bio-tech Co., Ltd.JSInfluenza, Influenza Vaccine
Start: 2025-11-13End: 2026-12-13Updated: 2026-02-19

Phase 2

Safety, Tolerability and Abeta-specific Antibody Response of Repeated i.m. Injections of Adjuvanted CAD106 in Mild Alzheimer Patients
CompletedNCT01097096
Novartis PharmaceuticalsAlzheimer's Disease
Start: 2010-03-31End: 2012-12-31Updated: 2021-03-05
H7N9 Mix and Match With MF59 in Healthy Adults
CompletedNCT01938742
National Institute of Allergy and Infectious Diseases (NIAID)Influenza
Start: 2013-09-30End: 2014-11-30Updated: 2016-12-12
H7N9 Mix and Match With AS03 and MF59 in Healthy Adults
CompletedNCT01942265
National Institute of Allergy and Infectious Diseases (NIAID)Influenza
Start: 2013-09-30End: 2015-01-31Updated: 2017-07-06
H7N9 Mix and Match With MF59 in Healthy Elderly Persons
CompletedNCT02213354
National Institute of Allergy and Infectious Diseases (NIAID)Avian Influenza
Start: 2014-10-31End: 2016-07-31Updated: 2017-07-06
Assess the Safety & Immunogenicity of Stored Inactivated Influenza H5N1 Virus Vaccine Given With & Without Stored MF59 Adjuvant
CompletedNCT02680002
Biomedical Advanced Research and Development AuthorityA/Vietnam/H5N1 Influenza Virus
Start: 2016-03-31End: 2017-03-31Updated: 2020-08-31
Panblok H7 Vaccine Adjuvanted With AS03 or MF59
CompletedNCT03283319
Biomedical Advanced Research and Development AuthorityInfluenza, Human
Start: 2017-09-20End: 2018-11-09Updated: 2020-05-06
Safety/Efficacy Study of Seqirus A/H7N9 IIV With or Without MF59(R) Adjuvant to Prevent Avian Influenza
CompletedNCT03682120
National Institute of Allergy and Infectious Diseases (NIAID)Avian Influenza, Influenza Immunisation
Start: 2018-11-02End: 2020-04-30Updated: 2021-05-17

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