Metyrapone

DRUG11 trials

Conditions

Autonomous Cortisol SecretionBrain InjuryCocaine AddictionCocaine DependenceCocaine-Related DisordersCraniocerebral TraumaCushing's SyndromeDepression

Phase 1

Cocaine-Metyrapone Interaction Study - 1

NCT00033098

National Institute on Drug Abuse (NIDA)Cocaine-Related Disorders, Infusions, Intravenous

Start: 2001-11-30End: 2002-05-31Target: 12Updated: 2017-01-11

To Investigate Effects GSK561679 on Part of the Body's System That Controls the Balance of Many of the Hormones.

CompletedNCT00426608

GlaxoSmithKlineDepressive Disorder and Anxiety Disorders

Start: 2006-10-06End: 2007-01-08Updated: 2017-09-11

Stress Biomarkers:Attaching Biological Meaning to Field Friendly Salivary Measures

CompletedNCT01673087

University of MichiganStress

Start: 2012-10-31End: 2017-08-15Updated: 2018-04-23

Phase 2

Metyrapone as Additive Treatment in Major Depression

CompletedNCT00125554

Universitätsklinikum Hamburg-EppendorfMajor Depressive Disorder

Start: 1998-05-31End: 2001-07-31Target: 63Updated: 2005-08-12

Metyrapone for Mild Autonomous Cortisol Secretion (MACS)

Active, not recruitingNCT06106295

Mayo ClinicAutonomous Cortisol Secretion, Mild Autonomous Cortisol Secretion (MACS)

Start: 2023-12-19End: 2028-02-01Target: 30Updated: 2025-09-22

Phase 3

Antiglucocorticoid Augmentation of antiDepressants in Depression

CompletedNCT01375920

Jane BarnesDepression

Start: 2011-02-28End: 2013-06-30Updated: 2014-07-17

Effects of Metyrapone in Patients With Endogenous Cushing's Syndrome

CompletedNCT02297945

HRA PharmaCushing's Syndrome

Start: 2015-04-30End: 2020-04-29Updated: 2020-09-25

Phase 4

Cortisol and Nutritional Sympathetic Responsiveness

NCT01620684

Baker Heart Research InstituteInsulin Resistance, Metabolic Syndrome, Obesity

Start: 2013-02-28Target: 24Updated: 2014-09-09

Effects of the Addition of Metyrapone to Antidepressant Therapy in Depression With Dexamethasone Suppression Test Non-suppression.

NCT03491696

Centre Hospitalier RouffachDepressive Disorder, Hormone Disturbance

Start: 2018-12-22End: 2022-09-30Target: 14Updated: 2020-09-09

Unknown Phase

Study of the Approximate Entropy of Adrenocorticotropic Hormone and Cortisol Secretion in Patients With Head Injury

NCT00006270

National Center for Research Resources (NCRR)Brain Injury, Craniocerebral Trauma

Start: 1998-02-28Target: 32Updated: 2005-06-24

A Placebo-Controlled Study of a Combination of Metyrapone and Oxazepam in Cocaine Addiction

CompletedNCT00567814

Embera NeuroTherapeutics, Inc.Cocaine Addiction, Cocaine Dependence

Start: 2007-12-31End: 2008-11-30Target: 45Updated: 2008-12-31

Related Papers

SUN-448 Overnight Metyrapone Therapy in Patients with Mild Autonomous Cortisol Secretion (MACS): An Open-Label Phase 2 Clinical Trial

Journal of the Endocrine Society2025-10-01