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Metolazone

DRUG11 trials

Sponsors

Region Hovedstaden, Region Hovedstaden, Yonsei University, Vanderbilt University, Policlinico Casilino ASL RMB, Yale University

Conditions

Acute Decompensated Heart FailureAcute Heart FailureChronic Kidney DiseaseCongestive Heart FailureDiuretic ResistanceEdemaEnd Stage Renal DiseaseHeart Failure

Phase 2

Ertugliflozin in Chronic Heart Failure
RecruitingNCT04438213
Yale UniversityHeart Failure
Start: 2021-03-10End: 2025-12-30Target: 60Updated: 2025-10-08
Efficacy of Diuretics in Kidney Disease
TerminatedNCT04542304
Stanford UniversityChronic Kidney Disease, End Stage Renal Disease
Start: 2021-03-01End: 2023-06-15Updated: 2025-06-05
Metolazone As Early Add On Therapy For Acute Decompensated Heart Failure
WithdrawnNCT05633758
Scripps HealthAcute Decompensated Heart Failure
Start: 2014-03-31End: 2016-03-31Updated: 2022-12-01
Add-on Diuretics in Acute Decompensated Heart Failure
RecruitingNCT07372040
Tanta UniversityAcute Decompensated Heart Failure
Start: 2026-02-01End: 2027-02-01Target: 66Updated: 2026-02-04

Phase 3

Sequential Nephron Blockade in Acute Heart Failure
NCT04163588
Policlinico Casilino ASL RMBAcute Heart Failure
Start: 2019-10-01End: 2020-12-31Target: 310Updated: 2019-11-19
OPTIMAL DIURETIC THERAPIES FOR ACUTE HEART FAILURE WITH VOLUME OVERLOAD
RecruitingCTIS2024-510633-17-00
Region Hovedstaden, Region Hovedstadenacute heart failure
Start: 2024-09-05Target: 939Updated: 2025-06-24

Phase 4

Comparison of Oral or Intravenous Thiazides vs Tolvaptan in Diuretic Resistant Decompensated Heart Failure
CompletedNCT02606253
Vanderbilt UniversityHeart Failure
Start: 2016-02-29End: 2018-10-31Updated: 2019-11-08
Diuretic Strategies in Acute Heart Failure Patients at High Risk for Diuretic Resistance
TerminatedNCT05986773
Stadtspital ZürichAcute Heart Failure, Diuretic Resistance
Start: 2023-10-10End: 2024-12-31Updated: 2025-02-14
Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload
RecruitingNCT06414759
Cairo UniversityAcute Decompensated Heart Failure, Edema, Volume Overload
Start: 2024-07-01End: 2025-03-30Target: 110Updated: 2024-07-24

Unknown Phase

A Prospective, Single-center, Randomized, Controlled, Open-label, Pilot Study to Compare the Effectiveness and Safety of DIuretics Add-On Strategy in Acute Decompensated Heart Failure Patients (DIOS II)
WithdrawnNCT02047422
Yonsei UniversityCongestive Heart Failure
Start: 2014-01-31End: 2016-02-29Updated: 2016-09-07
Comparative Efficacy and Safety of Acetazolamide Versus Metolazone as an Adjunct to Standard Therapy in Patients With Acute Decompensated Heart Failure
RecruitingNCT07199088
University of Health Sciences LahoreAcute Decompensated Heart Failure, Heart Failure, Diastolic, Heart Failure, Systolic
Start: 2025-10-11End: 2026-10-30Target: 320Updated: 2025-10-03

Related Papers

Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure: The 3T Trial.
2019-12-11110 citations