Methylnaltrexone bromide

DRUG7 trials

Conditions

ConstipationEndogenous and Esophageal SensitivityHealthy Adult SubjectsNeoplasmsOpioid-Induced ConstipationOpioid-Related DisordersOpioid-induced ConstipationPancreatic Cancer

Phase 1

Evaluate the Pharmacokinetics (PK) of Methylnaltrexone (MNTX) in Healthy Adult Subjects

CompletedNCT01366326

Bausch Health Americas, Inc.Healthy Adult Subjects

Start: 2010-07-31End: 2010-08-31Updated: 2019-11-29

Phase 2

Study of Subcutaneous Methylnaltrexone (MNTX) in the Treatment of Opioid-Induced Constipation During Rehabilitation After Orthopedic Procedures

CompletedNCT00640146

Bausch Health Americas, Inc.Opioid-induced Constipation

Start: 2007-10-19End: 2009-01-21Updated: 2019-09-04

Methylnaltrexone for Opioid-induced Constipation in Cancer Patients

CompletedNCT01004393

University of VermontConstipation, Neoplasms, Opioid-Related Disorders

Start: 2009-10-31End: 2013-12-31Updated: 2016-02-02

A Study of Methylnaltrexone Bromide (MNTX) in Participants With Advanced Pancreatic Cancer

WithdrawnNCT04083651

Bausch Health Americas, Inc.Pancreatic Cancer

Start: 2020-01-06End: 2023-10-15Updated: 2021-05-07

Phase 3

Methylnaltrexone for Treatment of Opiate-Induced Constipation in the Intensive Care Unit

NCT01050595

St. John Health System, MichiganOpioid-induced Constipation

Start: 2009-12-31End: 2010-12-31Target: 80Updated: 2010-01-15

Phase 4

Safety of Subcutaneous Methylnaltrexone for Opioid-Induced Constipation in Patients With Advanced Illness

CompletedNCT00672139

Bausch Health Americas, Inc.Opioid-Induced Constipation

Start: 2008-07-31End: 2013-05-31Updated: 2018-03-07

Unknown Phase

The Effect of Naloxone and Methylnaltrexone on Esophageal Sensitivity in Health

CompletedNCT03014843

Universitaire Ziekenhuizen KU LeuvenEndogenous and Esophageal Sensitivity

Start: 2013-10-31End: 2014-01-31Updated: 2017-01-09

Related Papers

Subcutaneous Methylnaltrexone as Treatment for Opioid-Induced Constipation in Patients with Advanced Cancer and Noncancer Illnesses: A Post Hoc Analysis of Two Clinical Trials.

2023-02-101 citations

Phase II trial of subcutaneous methylnaltrexone in the treatment of severe opioid-induced constipation (OIC) in cancer patients: an exploratory study.

2016-09-158 citations