methotrexate/hydrocortisone/cytarabine

DRUG3 trials

Sponsors

St. Jude Children's Research Hospital

Conditions

Acute Leukemia of Ambiguous Lineage in RelapseAcute Lymphoblastic Leukemia (ALL)Acute Myeloid Leukemia (AML)Acute Myeloid Leukemia, in RelapseMixed Phenotype Acute Leukemia (MPAL)Myelodysplastic Syndrome (MDS)Refractory Acute Leukemia of Ambiguous LineageRefractory Acute Myeloid Leukemia

Phase 1

Selinexor With Fludarabine and Cytarabine for Treatment of Refractory or Relapsed Leukemia or Myelodysplastic Syndrome

CompletedNCT02212561

St. Jude Children's Research HospitalAcute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), Mixed Phenotype Acute Leukemia (MPAL) +1

Start: 2014-08-31End: 2015-12-31Updated: 2020-03-26

Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

Active, not recruitingNCT04898894

St. Jude Children's Research HospitalAcute Leukemia of Ambiguous Lineage in Relapse, Acute Myeloid Leukemia, in Relapse, Refractory Acute Leukemia of Ambiguous Lineage +1

Start: 2021-11-15End: 2027-09-01Updated: 2026-04-28

Phase 2

Selinexor in Combination With Fludarabine and Cytarabine in Patients With Refractory or Relapsed Acute Myeloid Leukemia

TerminatedNCT03071276

St. Jude Children's Research HospitalAcute Myeloid Leukemia (AML)

Start: 2016-01-14End: 2019-04-30Updated: 2020-05-22

Related Papers

Preliminary Safety and Efficacy of Venetoclax and Selinexor in Combination with Chemotherapy in Pediatric and Young Adult Patients with Relapsed or Refractory Acute Myeloid Leukemia: Selclax

Blood2023-11-022 citations

Selinexor Prolongs Survival in Patient-Derived Xenograft Models of Down Syndrome Myeloid Leukemia

Blood2022-11-153 citations

Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis

Blood2017-06-1971 citations

Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Combination With Fludarabine and Cytarabine, in Pediatric Relapsed or Refractory Acute Leukemia

Journal of Clinical Oncology2016-08-10120 citations

Nuclear Export Inhibitor KPT-8602 Is Highly Active Against Leukemic Blasts and Leukemia-Initiating Cells in Patient-Derived Xenograft Models of AML

Blood2015-12-03