Metastasectomy

PROCEDURE11 trials

Sponsors

University College, London, M.D. Anderson Cancer Center, National Cancer Institute (NCI), University of Utah, Roswell Park Cancer Institute

Conditions

AdenocarcinomaAdenocarcinoma of the StomachBladder Urothelial CarcinomaCastration-resistant Prostate CancerClear Cell Renal Cell CarcinomaColo-rectal CancerColorectal AdenocarcinomaColorectal Cancer

Early Phase 1

Nivolumab With or Without Bevacizumab or Ipilimumab Before Surgery in Treating Patients With Metastatic Kidney Cancer That Can Be Removed by Surgery

Active, not recruitingNCT02210117

M.D. Anderson Cancer CenterClear Cell Renal Cell Carcinoma, Metastatic Kidney Carcinoma, Stage IV Renal Cell Cancer AJCC v7

Start: 2014-11-25End: 2026-11-30Updated: 2026-01-07

Daratumumab in Treating Patients with Muscle Invasive Bladder Cancer or Metastatic Kidney Cancer

CompletedNCT03473730

M.D. Anderson Cancer CenterBladder Urothelial Carcinoma, Clear Cell Renal Cell Carcinoma, Malignant Urinary System Neoplasm +2

Start: 2018-05-29End: 2025-01-27Updated: 2025-01-30

EGF-Depleting Therapy CIMAvax-EGF in Combination With Standard Therapy for RAS- and BRAF Wild-Type Metastatic Colorectal Cancer

Active, not recruitingNCT06011772

Roswell Park Cancer InstituteColo-rectal Cancer

Start: 2023-12-18End: 2026-12-04Updated: 2026-03-11

Phase 1

Nivolumab in Treating Patients With High-Risk Kidney Cancer Before Surgery

TerminatedNCT02595918

National Cancer Institute (NCI)Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v7 +3

Start: 2016-05-19End: 2020-08-01Updated: 2020-10-23

Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal Metastases

RecruitingNCT03965234

Roswell Park Cancer InstituteColorectal Cancer, Metastatic Bone Sarcoma, Metastatic Malignant Neoplasm in the Lung +3

Start: 2020-07-16End: 2030-05-25Target: 99Updated: 2026-03-17

Phase 2

Liver Surgery and Chemotherapy in Treating Patients With Colorectal Cancer With Liver Metastases That Can Be Removed by Surgery and Lung Metastases That Cannot Be Removed by Surgery

TerminatedNCT02738606

M.D. Anderson Cancer CenterMetastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver, Metastatic Malignant Neoplasm in the Lung +5

Start: 2016-09-23End: 2025-12-05Updated: 2026-02-17

Chemotherapy and/or Metastasectomy in Treating Patients With Metastatic Colorectal Adenocarcinoma With Lung Metastases

Active, not recruitingNCT03599752

M.D. Anderson Cancer CenterColorectal Adenocarcinoma, Colorectal Carcinoma Metastatic in the Lung, Stage IVA Colorectal Cancer AJCC v8 +3

Start: 2018-07-02End: 2030-01-31Updated: 2026-01-09

Salvage Oligometastasectomy and Radiation Therapy in Recurrent Prostate Cancer

Active, not recruitingNCT03796767

University of UtahMetastatic Malignant Neoplasm in the Bone, Metastatic Malignant Neoplasm in the Lymph Nodes, Oligometastasis +3

Start: 2019-09-09End: 2026-06-30Updated: 2026-01-28

Radiotherapy + Chemoimmunotherapy Followed by Surgery in Patients With Limited Metastatic Gastric or GEJ Cancer

RecruitingNCT06121700

Fudan UniversityAdenocarcinoma, Adenocarcinoma of the Stomach, Gastroesophageal Junction Adenocarcinoma +6

Start: 2023-01-01End: 2027-12-31Target: 55Updated: 2023-11-08

Phase 3

Metastasis-directed Therapy in Oligoprogressive Castration-refractory Prostate Cancer

RecruitingNCT06585007

Universitaire Ziekenhuizen KU LeuvenCastration-resistant Prostate Cancer, Oligoprogressive

Start: 2023-12-19End: 2029-01-20Target: 246Updated: 2024-09-05

Unknown Phase

A Randomised Trial of Pulmonary Metastasectomy in Colorectal Cancer

CompletedNCT01106261

University College, LondonColorectal Cancer, Pulmonary Metastases

Start: 2010-12-02End: 2020-02-29Updated: 2023-05-11

Related Papers

Genomic and Molecular Associations with Preoperative Immune Checkpoint Inhibition in Patients with Stage III Clear Cell Renal Cell Carcinoma.

2026-01-20

Immune checkpoint inhibitors plus debulking surgery for patients with metastatic renal cell carcinoma: clinical outcomes and immunological correlates of a prospective pilot trial.

2025-02-219 citations

Phase II trial of image-guided oligometastatectomy and radiation therapy in recurrent prostate cancer (SOAR).

Journal of Clinical Oncology2025-02-10

Abstract CT126: A Phase 0 Study of EGF-Depleting Therapy CIMAvax-EGF in Combination With Standard Therapy for RAS- and BRAF Wild-Type Metastatic Colorectal Cancer

Cancer Research2024-04-052 citations

Spatiotemporal evolution of the clear cell renal cell carcinoma microenvironment links intra-tumoral heterogeneity to immune escape.

2022-12-1941 citations

Study Protocol for a Randomised Controlled Trial on Pulmonary Metastasectomy vs. Standard of Care in Colorectal Cancer Patients With ≥ 3 Lung Metastases (PUCC-Trial)

Frontiers in Oncology2022-07-118 citations

Reply from author: What is the right answer for pulmonary metastatic disease? More clinical trials

JTCVS Open2021-09-161 citations

The role of nephrectomy in metastatic renal cell carcinoma in the immuno‐oncology era

British Journal of Urology2021-04-0910 citations

A pilot study of preoperative nivolumab in high-risk nonmetastatic renal cell carcinoma.

Journal of Clinical Oncology2021-02-205 citations

Pulmonary Metastasectomy versus Continued Active Monitoring in Colorectal Cancer (PulMiCC): a multicentre randomised clinical trial.

2019-12-12134 citations

Abstract 4488: Effector B cells and tertiary lymphoid structures predict response to immune checkpoint blockade in solid tumors

Cancer Research2019-07-01

Abstract 4488: Effector B cells and tertiary lymphoid structures predict response to immune checkpoint blockade in solid tumors

Immunology2019-07-01

A pilot randomized study evaluating nivolumab (nivo) or nivo + bevacizumab (bev) or nivo + ipilimumab (ipi) in patients with metastatic renal cell carcinoma (MRCC) eligible for cytoreductive nephrectomy, metastasectomy or post-treatment biopsy (Bx).

Journal of Clinical Oncology2019-05-2012 citations

PROSPER: A phase III randomized study comparing perioperative nivolumab (nivo) versus observation in patients with renal cell carcinoma (RCC) undergoing nephrectomy (ECOG-ACRIN 8143).

Journal of Clinical Oncology2019-05-207 citations

A pilot randomized study evaluating nivolumab (nivo) or nivo + bevacizumab (bev) or nivo + ipilimumab (ipi) in patients with metastatic renal cell carcinoma (MRCC) eligible for cytoreductive nephrectomy (CN), metastasectomy (MS) or post-treatment biopsy (Bx).

Journal of Clinical Oncology2018-05-2013 citations

PROSPER: A phase III randomized study comparing perioperative nivolumab (nivo) vs. observation in patients with localized renal cell carcinoma (RCC) undergoing nephrectomy (ECOG-ACRIN 8143).

Journal of Clinical Oncology2018-05-201 citations

Abstract CT083: Clinical activity, immune and molecular correlates of nivolumab vs. nivolumab plus bevacizumab vs nivolumab plus ipilimumab in metastatic renal cell carcinoma

Cancer Research2017-07-014 citations

LUNA: A randomized phase II trial of liver resection plus chemotherapy or chemotherapy alone in patients with unresectable lung and resectable liver metastases from colorectal adenocarcinoma.

Journal of Clinical Oncology2017-05-205 citations