MET-4

DRUG3 trials

Sponsors

University Health Network, Toronto, Canadian Cancer Trials Group

Conditions

Advanced Head and Neck Squamous Cell CarcinomaAll Solid TumorsHead and Neck Squamous Cell Carcinoma

Phase 2

Feasibility Study of MET-4: Evaluating Fecal Microbiome Effects in Immunotherapy Patients

Active, not recruitingNCT03686202

University Health Network, TorontoAll Solid Tumors

Start: 2018-11-30End: 2026-12-01Target: 65Updated: 2026-02-09

PembROlizumab With or Without Microbial EcOsystem ThErapeutic 4 (MET4) in Advanced Head and Neck Squamous Cell Carcinoma

WithdrawnNCT05743777

Canadian Cancer Trials GroupAdvanced Head and Neck Squamous Cell Carcinoma

Start: 2023-05-12End: 2023-05-12Updated: 2023-05-18

Unknown Phase

Role of Microbiome as a Biomarkers in Locoregionally-Advanced Oropharyngeal Squamous Cell Carcinoma 2

CompletedNCT03838601

University Health Network, TorontoHead and Neck Squamous Cell Carcinoma

Start: 2019-07-02End: 2025-09-16Updated: 2026-06-08

Related Papers

Autoimmune PaneLs as PrEdictors of Toxicity in Patients TReated with Immune Checkpoint InhibiTors (ALERT)

Journal of Experimental & Clinical Cancer Research2023-10-218 citations

Customized autoantibodies (autoAbs) profiling to predict and monitor immune-related adverse events (irAEs) in patients receiving immune checkpoint inhibitors (ICI).

Journal of Clinical Oncology2022-06-0126 citations

Prospective manipulation of the gut microbiome with Microbial Ecosystem Therapeutic 4 (MET4) in locoregionally advanced oropharyngeal squamous cell carcinoma (LA-OPSCC) undergoing primary chemoradiation (ROMA2).

Journal of Clinical Oncology2021-05-202 citations

First-in-class microbial ecosystem therapeutics 4 (MET4) in metastatic solid cancer patients treated with immunotherapy: MET4-IO.

Journal of Clinical Oncology2020-05-2028 citations

Feasibility study of microbial ecosystem therapeutics (MET-4) to evaluate effects of fecal microbiome in patients on immunotherapy (MET4-IO).

Journal of Clinical Oncology2019-05-204 citations