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MET-2

BIOLOGICAL6 trials

Sponsors

NuBiyota, University Health Network, Toronto

Conditions

Antibiotic Resistant InfectionAnxietyClostridium Difficile InfectionDepression, AnxietyGram-negative BacteremiaMajor Depressive DisorderMicrobial ColonizationObesity

Early Phase 1

Safety and Efficacy of MET-3 in Obese Human Subjects
CompletedNCT03660748
NuBiyotaObesity
Start: 2018-10-01End: 2020-01-22Updated: 2020-08-11

Phase 1

MET-2 Clinical Study for Recurrent Clostridium Difficile Infection (CDI)
CompletedNCT02865616
NuBiyotaClostridium Difficile Infection
Start: 2017-10-27End: 2020-03-17Updated: 2020-08-11
Safety and Efficacy of Microbial Ecosystem Therapeutic-2 (MET-2) in Patients With Ulcerative Colitis (UC)
CompletedNCT03832400
NuBiyotaUlcerative Colitis
Start: 2019-02-04End: 2020-03-01Updated: 2021-05-03
The Safety, Efficacy, and Tolerability of Microbial Ecosystem Therapeutic-2 in People With Major Depression and/or Generalized Anxiety Disorder
CompletedNCT04052451
NuBiyotaDepression, Anxiety
Start: 2019-05-16End: 2020-05-01Updated: 2020-08-11

Phase 2

The Safety, Efficacy, and Tolerability of Microbial Ecosystem Therapeutic-2 in People With Major Depression
NCT04602715
NuBiyotaAnxiety, Major Depressive Disorder
Start: 2021-04-01End: 2021-06-30Target: 60Updated: 2021-05-11
Antimicrobial Resistant Organism Decolonization After Microbiome Perturbation
WithdrawnNCT06214403
University Health Network, TorontoAntibiotic Resistant Infection, Gram-negative Bacteremia, Microbial Colonization
Start: 2026-07-01End: 2028-07-01Updated: 2026-03-12

Related Papers

The Safety and Efficacy of Microbial Ecosystem Therapeutic-2 in People With Major Depression – A Phase 2, Double-Blind, Placebo-Controlled Study: Clinical Results: Innocuité et efficacité du traitement de l'écosystème microbien (met–2) dans la dépression majeure – une étude de phase 2 à double insu contrölée par placebo : résultats cliniques
The Canadian Journal of Psychiatry2025-03-211 citations
Microbial Ecosystem Therapeutic-2 Intervention in People With Major Depressive Disorder and Generalized Anxiety Disorder: Phase 1, Open-Label Study
Interactive Journal of Medical Research2022-01-2117 citations
The Safety and Efficacy of Microbial Ecosystem Therapeutic-2 in People With Major Depression: Protocol for a Phase 2, Double-Blind, Placebo-Controlled Study
JMIR Research Protocols2021-07-2012 citations
The effect of a microbial ecosystem therapeutic (MET-2) on recurrent Clostridioides difficile infection: a phase 1, open-label, single-group trial.
2021-02-2361 citations