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Mazdutide(Dual GLP-1R/GCGR Agonist)

DRUG2 trials

Sponsors

Tianjin Medical University, Tongji Hospital

Conditions

Atypical Endometrial HyperplasiaEndometrial Carcinoma Stage IEndometrioid Endometrial CancerNonalcoholic Fatty Liver Disease (NAFLD) With History of Diabetes MelitusObesityOverweightType 2 Diabetes Mellitus (T2DM)

Phase 2

Mazdutide Plus LNG-IUS for Fertility-Sparing Treatment of AEH or Early Endometrial Cancer
Not yet recruitingNCT07781150
Tongji HospitalObesity, Overweight, Atypical Endometrial Hyperplasia +2
Start: 2026-11-01End: 2031-06-30Target: 128Updated: 2026-08-24

Unknown Phase

Efficacy and Safety of Mazdutide in Patients With Type 2 Diabetes Mellitus and Moderate to Severe Nonalcoholic Fatty Liver Disease Previously Treated With Semaglutide
Not yet recruitingNCT07713992
Tianjin Medical UniversityType 2 Diabetes Mellitus (T2DM), Nonalcoholic Fatty Liver Disease (NAFLD) With History of Diabetes Melitus
Start: 2026-09-15End: 2028-02-01Target: 72Updated: 2026-07-20