Mazdutide

DRUG8 trials

Conditions

Alcohol Use DisorderCoronary Heart DiseaseDementia, MildImpaired Fasting GlucoseImpaired Glucose Tolerance (Prediabetes)Mild Cognitive ImpairmentObesityObesity & Overweight

Phase 1

Efficacy of Mazdutide for Treating PCOS

RecruitingNCT06519656

Shanghai Zhongshan HospitalPolycystic Ovary Syndrome

Start: 2024-10-21End: 2026-06-30Target: 50Updated: 2024-10-24

Phase 2

A Study of LY3305677 Compared With Placebo in Adult Participants With Obesity or Overweight

CompletedNCT06124807

Eli Lilly and CompanyObesity, Overweight and Obesity

Start: 2023-11-17End: 2025-07-09Updated: 2026-04-21

A Study to Evaluate Mazdutide Compared With Placebo in Participants With Alcohol Use Disorder

CompletedNCT06817356

Eli Lilly and CompanyAlcohol Use Disorder

Start: 2025-02-06End: 2026-05-19Updated: 2026-07-16

Phase 3

GLP-1/GCG Dual Agonist in Type 2 Diabetes With Early Dementia (LIGHT-COG Study)

RecruitingNCT07083154

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolDementia, Mild, Mild Cognitive Impairment, Type 2 Diabetes

Start: 2025-09-27End: 2029-08-01Target: 420Updated: 2026-03-05

A Study of HDM1005 in Participants With T2DM Not Controlled With Metformin Alone or in Combination With a Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor

Not yet recruitingNCT07417306

Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.Type 2 Diabetes

Start: 2026-03-27End: 2027-12-31Target: 912Updated: 2026-02-18

Phase 4

Mazdutide for Adults With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled Trial (DREAM-PRE)

Not yet recruitingNCT07654062

Shandong Provincial HospitalImpaired Fasting Glucose, Impaired Glucose Tolerance (Prediabetes), Prediabetes

Start: 2026-07-01End: 2029-07-01Target: 150Updated: 2026-06-17

Effect of Mazdutide on Coronary Plaque in Patients With Coronary Atherosclerosis and Overweight or Obesity

Not yet recruitingNCT07657676

China National Center for Cardiovascular DiseasesCoronary Heart Disease, Obesity & Overweight

Start: 2026-05-25End: 2028-02-28Target: 116Updated: 2026-06-18

Unknown Phase

ASCEND-1: Lifestyle Intervention Plus Mazdutide for Weight Management

RecruitingNCT07517042

Shanghai Zhongshan HospitalObesity, Weight Control

Start: 2026-04-01End: 2028-12-01Target: 420Updated: 2026-04-08

Related Papers

1733-P: Effect of Mazdutide on Kidney Function in Adults with Obesity or Overweight

Diabetes2026-06-05

1693-P: Mazdutide Improves Markers of Insulin Sensitivity in Adults with Obesity without Type 2 Diabetes