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Mazdutide

DRUG15 trials

Sponsors

Eli Lilly and Company, Shanghai Zhongshan Hospital, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd., Shandong Provincial Hospital

Conditions

Ablation TreatmentAlcohol Use DisorderAtrial Fibrillation (AF)Coronary Heart DiseaseDementia, MildDiabetes Mellitus, Type 2Fatty PancreasGout

Phase 1

Efficacy of Mazdutide for Treating PCOS
CompletedNCT06519656
Shanghai Zhongshan HospitalPolycystic Ovary Syndrome
Start: 2024-10-21End: 2026-09-18Updated: 2026-09-21

Phase 2

A Study of LY3305677 Compared With Placebo in Adult Participants With Obesity or Overweight
CompletedNCT06124807
Eli Lilly and CompanyObesity, Overweight and Obesity
Start: 2023-11-17End: 2025-07-09Updated: 2026-04-21
A Study to Evaluate Mazdutide Compared With Placebo in Participants With Alcohol Use Disorder
CompletedNCT06817356
Eli Lilly and CompanyAlcohol Use Disorder
Start: 2025-02-06End: 2026-05-19Updated: 2026-07-16
A Study of HRS-4729 Injection in Participants With Type 2 Diabetes
Not yet recruitingNCT07843862
Fujian Shengdi Pharmaceutical Co., Ltd.Type 2 Diabetes
Start: 2026-10-01End: 2027-07-01Target: 240Updated: 2026-09-28

Phase 3

Mazdutide in Type 2 Diabetes With Early-Stage Cognitive Impairment (LIGHT-COG Study)
RecruitingNCT07083154
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolDementia, Mild, Mild Cognitive Impairment, Type 2 Diabetes
Start: 2025-09-27End: 2029-08-01Target: 420Updated: 2026-09-02
A Study of HDM1005 in Participants With T2DM Not Controlled With Metformin Alone or in Combination With a Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor
Not yet recruitingNCT07417306
Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.Type 2 Diabetes
Start: 2026-03-27End: 2027-12-31Target: 912Updated: 2026-02-18

Phase 4

Mazdutide for Adults With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled Trial (DREAM-PRE)
Not yet recruitingNCT07654062
Shandong Provincial HospitalImpaired Fasting Glucose, Impaired Glucose Tolerance (Prediabetes), Prediabetes
Start: 2026-07-01End: 2029-07-01Target: 150Updated: 2026-06-17
Effect of Mazdutide on Coronary Plaque in Patients With Coronary Atherosclerosis and Overweight or Obesity
RecruitingNCT07657676
China National Center for Cardiovascular DiseasesCoronary Heart Disease, Obesity & Overweight
Start: 2026-09-14End: 2027-12-31Target: 116Updated: 2026-10-13
Pre-hepatectomy Rehabilitation in Obese MASLD-Complicated Living Liver Donors With Mazdutide (PRIME)
RecruitingNCT07718126
West China HospitalHepatic Steatosis, Living Liver Donors, Metabolic Dysfunction-Associated Steatohepatitis
Start: 2026-09-01End: 2029-08-31Target: 60Updated: 2026-09-23
QUARTET-DKD: Quadruple Therapy for Type 2 Diabetic Nephropathy
Not yet recruitingNCT07775846
Huijie ZhangType 2 Diabetic Kidney Disease
Start: 2026-09-01End: 2029-06-30Target: 820Updated: 2026-08-20
Mazdutide for Weight Management and Gout in Adults With Obesity
Not yet recruitingNCT07824895
Hongwei JiangGout, Hyperuricemia, Metabolic Syndrome +1
Start: 2026-09-15End: 2028-03-31Target: 30Updated: 2026-09-17

Unknown Phase

ASCEND-1: Lifestyle Intervention Plus Mazdutide for Weight Management
RecruitingNCT07517042
Shanghai Zhongshan HospitalObesity, Weight Control
Start: 2026-06-10End: 2028-12-01Target: 420Updated: 2026-10-22
Mazdutide for Remission of Type 2 Diabetes: Multicentre, Double Blind, Randomised, Placebo Controlled Trial
Not yet recruitingNCT07767552
Yanbing LiDiabetes Mellitus, Type 2
Start: 2026-09-30End: 2029-06-30Target: 249Updated: 2026-08-17
Efficacy of Mazdutide on Fatty Pancreas
Not yet recruitingNCT07803705
Tongji HospitalFatty Pancreas, Obesity, Overweight
Start: 2026-11-15End: 2028-12-30Target: 194Updated: 2026-09-22
Mazdutide for Reducing Atrial Fibrillation Recurrence After Catheter Ablation in Obese Patients
Not yet recruitingNCT07897305
Beijing Anzhen HospitalAblation Treatment, Atrial Fibrillation (AF), Mazdutide +1
Start: 2026-10-25End: 2028-12-30Target: 700Updated: 2026-10-27

Related Papers

Efficacy and safety of mazdutide in adults with obesity or overweight: a US-based, multicentre, phase 2, randomised, placebo-controlled clinical trial.
2026-08-21
1733-P: Effect of Mazdutide on Kidney Function in Adults with Obesity or Overweight
Diabetes2026-06-05
1693-P: Mazdutide Improves Markers of Insulin Sensitivity in Adults with Obesity without Type 2 Diabetes
Diabetes2026-06-05