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Matched placebo for test product

DRUG16 trials

Sponsors

Sanofi-Aventis Recherche & Developpement

Conditions

BronchiectasisChronic Obstructive Pulmonary DiseaseChronic rhinosinusitis with nasal polypsDigestive system diseasesImmune system diseasesImmune system disseasesNeurodermatitisNutritional and metabolic diseases

Phase 2

Phase 3

A double-blinded extension study to evaluate the long-term safety and tolerability of itepekimab in patients with chronic obstructive pulmonary disease (COPD) who participated in either EFC16750 or EFC16819 clinical studies
Active, not recruitingCTIS2023-508085-15-00
Sanofi-Aventis Recherche & DeveloppementChronic Obstructive Pulmonary Disease
Start: 2024-05-15Target: 247Updated: 2026-01-20
Randomized, double-blind, placebo-controlled, parallel-group Phase 3 study to evaluate the efficacy, safety, and tolerability of SAR440340/REGN3500/itepekimab (anti-IL-33 mAb) in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD) (AERIFY-1)
CompletedCTIS2024-512013-41-00
Sanofi-Aventis Recherche & DeveloppementChronic Obstructive Pulmonary Disease
Start: 2021-03-22End: 2025-06-24Target: 686Updated: 2025-03-25
Randomized, double-blind, placebo-controlled, parallel-group Phase 3 study to evaluate the efficacy, safety, and tolerability of SAR440340/REGN3500/itepekimab (anti-IL-33 mAb) in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD)
CompletedCTIS2024-512012-21-00
Sanofi-Aventis Recherche & DeveloppementChronic Obstructive Pulmonary Disease
Start: 2021-04-08End: 2025-08-05Target: 747Updated: 2025-03-24
A Phase 3, randomized, double-blind, placebo-controlled, parallel-group study to investigate the efficacy and safety of dupilumab for the treatment of pruritus of Lichen Simplex Chronicus (LSC) in adults
Active, not recruitingCTIS2024-514762-39-00
Sanofi-Aventis Recherche & DeveloppementNeurodermatitis
Start: 2025-03-03Target: 69Updated: 2025-07-18
A Phase 3, randomized, double-blind, placebo-controlled, parallel-group study to investigate the efficacy and safety of dupilumab for the treatment of pruritus of Lichen Simplex Chronicus (LSC) in adults
RecruitingCTIS2024-514737-37-00
Sanofi-Aventis Recherche & DeveloppementNeurodermatitis
Start: 2025-03-06Target: 77Updated: 2025-07-18
A randomized, double blind, placebo controlled, parallel group, 52­week Phase 3 trial to investigate the efficacy, safety, and tolerability of itepekimab in adult participants with inadequately-controlled chronic rhinosinusitis with nasal polyps
RecruitingCTIS2024-516814-39-00
Sanofi-Aventis Recherche & DeveloppementChronic rhinosinusitis with nasal polyps
Start: 2025-05-20Target: 131Updated: 2026-01-23
A randomized, double blind, placebo controlled, parallel group, 52­week Phase 3 trial to investigate the efficacy, safety, and tolerability of itepekimab in adult participants with inadequately-controlled chronic rhinosinusitis with nasal polyps
RecruitingCTIS2024-516815-26-00
Sanofi-Aventis Recherche & DeveloppementChronic rhinosinusitis with nasal polyps
Start: 2025-05-30Target: 135Updated: 2025-11-23
A randomized, double-blind, Phase 3 study to investigate efficacy and safety of teplizumab compared with placebo in participants 1 to 25 years of age with recently diagnosed Stage 3 Type 1 Diabetes (T1D) (βETA PRESERVE)
RecruitingCTIS2024-519494-19-00
Sanofi-Aventis Recherche & DeveloppementNutritional and metabolic diseases
Start: 2025-12-22Target: 467Updated: 2025-11-30
A Multicenter, Multinational, Randomized, Double-blind, Placebo-Controlled, Phase 3 Maintenance Study to Evaluate the Efficacy and Safety of Duvakitug in Participants with Moderately to Severely Active Ulcerative Colitis
Not yet recruitingCTIS2025-521038-27-00
Sanofi-Aventis Recherche & DeveloppementImmune system diseases
Target: 89Updated: 2026-02-10
A multicenter, multinational, randomized, double-blind, placebo-controlled Phase 3, induction study to evaluate the efficacy and safety of duvakitug in participants with moderately to severely active Ulcerative Colitis.
Not yet recruitingCTIS2025-521035-37-00
Sanofi-Aventis Recherche & DeveloppementImmune system diseases
Target: 210Updated: 2026-02-10
A multicenter, multinational, randomized, double-blind, placebo-controlled Phase 3, maintenance study to evaluate the efficacy and safety of duvakitug in participants with moderately to severely active Crohn’s disease
Not yet recruitingCTIS2025-521037-86-00
Sanofi-Aventis Recherche & DeveloppementImmune system diseases
Target: 114Updated: 2026-02-25
A multicenter, multinational, randomized, double-blind, placebo-controlled Phase 3, induction study to evaluate the efficacy and safety of duvakitug in participants with moderately to severely active Crohn’s Disease
Not yet recruitingCTIS2025-521036-11-00
Sanofi-Aventis Recherche & DeveloppementImmune system disseases
Target: 324Updated: 2026-02-25

Phase 4