Malarone

DRUG5 trials

Sponsors

U.S. Army Medical Research and Development Command, Radboud University Medical Center, Medicines for Malaria Venture, Walter Reed Army Institute of Research (WRAIR)

Conditions

BioavailabilityExerciseMalariaPharmacokineticsPlasmodium FalciparumPlasmodium Falciparum, Malaria

Phase 1

DSM265 Chemoprophylaxis of Plasmodium Falciparum Malaria

CompletedNCT02450578

Medicines for Malaria VenturePlasmodium Falciparum, Malaria

Start: 2015-10-31End: 2016-04-30Updated: 2021-01-13

Atoguanil BA Study

CompletedNCT04866602

Medicines for Malaria VentureBioavailability

Start: 2021-11-17End: 2022-03-18Updated: 2022-05-05

Phase 2

Safety and Efficacy Study of IV Artesunate to Treat Malaria

CompletedNCT00298610

U.S. Army Medical Research and Development CommandMalaria

Start: 2006-03-31End: 2007-10-31Updated: 2019-10-01

Phase 4

Malarone Pharmacokinetics Under Simulated Physiologic Stressors of Deployment

WithdrawnNCT03991208

Walter Reed Army Institute of Research (WRAIR)Exercise, Pharmacokinetics

Start: 2019-05-24End: 2021-05-23Updated: 2021-04-30

Unknown Phase

Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine Versus Mefloquine Prophylaxis

CompletedNCT01422954

Radboud University Medical CenterMalaria, Plasmodium Falciparum

Start: 2012-01-31End: 2013-04-30Updated: 2013-04-29

Related Papers

A randomized, open-label two-period crossover pilot study to evaluate the relative bioavailability in the fed state of atovaquone-proguanil (Atoguanil™) versus atovaquone-proguanil hydrochloride (Malarone®) in healthy adult participants.

2024-06-25

DSM265 for Plasmodium falciparum chemoprophylaxis: a randomised, double blinded, phase 1 trial with controlled human malaria infection.

2017-03-2875 citations

Sporozoite Immunization of Human Volunteers under Mefloquine Prophylaxis Is Safe, Immunogenic and Protective: A Double-Blind Randomized Controlled Clinical Trial

PLoS ONE2014-11-1450 citations