Malaria challenge

OTHER4 trials

Sponsors

U.S. Army Medical Research and Development Command, National Institute of Allergy and Infectious Diseases (NIAID)

Conditions

Malaria, FalciparumPlasmodium Falciparum InfectionPlasmodium Vivax Malaria

Phase 1

Clinical Trial for the Development of a Safe Malaria Challenge Model That Can be Reproduced in Humans

CompletedNCT00935623

U.S. Army Medical Research and Development CommandPlasmodium Vivax Malaria

Start: 2009-04-21End: 2011-09-30Updated: 2018-08-16

Safety and Preliminary Efficacy of the Malaria Vaccine Candidates Falciparum Merozoite Protein-1 (FMP1) and SmithKlineBeecham (SKBB) Candidate Malaria Vaccine RTS,S

CompletedNCT01556945

U.S. Army Medical Research and Development CommandMalaria, Falciparum

Start: 2001-04-30Updated: 2014-05-02

Trial to Evaluate the Safety, Immunogenicity and Protective Efficacy of Three or Five Administrations of GAP3KO Sporozoites

CompletedNCT03168854

National Institute of Allergy and Infectious Diseases (NIAID)Plasmodium Falciparum Infection

Start: 2017-07-26End: 2019-08-16Updated: 2025-02-24

rCSP/AP10-602 [GLA-LSQ] Vaccine Trial

CompletedNCT03589794

National Institute of Allergy and Infectious Diseases (NIAID)Plasmodium Falciparum Infection

Start: 2018-12-21End: 2022-07-05Updated: 2023-07-10

Related Papers

A phase IIa, randomized, double-blind, safety, immunogenicity and efficacy trial of Plasmodium falciparum vaccine antigens merozoite surface protein 1 and RTS,S formulated with AS02 adjuvant in healthy, malaria-naïve adults

Vaccine2024-04-013 citations

Recombinant Full-length <i>Plasmodium falciparum</i> Circumsporozoite Protein–Based Vaccine Adjuvanted With Glucopyranosyl Lipid A–Liposome <i>Quillaja saponaria</i> 21: Results of Phase 1 Testing With Malaria Challenge

The Journal of Infectious Diseases2024-02-085 citations

Low dose recombinant full-length circumsporozoite protein-based Plasmodium falciparum vaccine is well-tolerated and highly immunogenic in phase 1 first-in-human clinical testing.

2021-01-2215 citations