Skip to content

MabThera 100 mg concentrate for solution for infusion

DRUG17 trials

Sponsors

Merck Sharp & Dohme LLC, Amsterdam UMC, UZ Leuven, BeOne Medicines AG, Epizyme Inc.

Conditions

Adult patients with indolent MCL who have not previously received treatment (naïve patients).Chronic lymphocytic leukemiaChronic lymphotic leukemia and Small Lymphocytic lymphomaMantle Cell LymphomaMinimal Change Nephrotic SyndromNEPHROTIC SYNDROMEPotential malignancy in patients who received treatment with Autolus CAR T cell therapy.Previously untreated patients with diagnosis of HCL

Phase 2

A Phase 2/3 Multicenter, Open-label, Randomized, Active-Control Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (waveLINE-003)
RecruitingCTIS2022-502646-27-00
Merck Sharp & Dohme LLCRelapsed or Refractory Diffuse Large B-Cell Lymphoma
Start: 2022-06-24Target: 35Updated: 2025-11-17
Full title of the clinical trial: A Phase 3 Randomized, Open-Label, Multicenter Study Comparing Zanubrutinib (BGB-3111) plus Rituximab Versus Bendamustine plus Rituximab in Patients with Previously Untreated Mantle Cell Lymphoma Who Are Ineligible for Stem Cell Transplantation
RecruitingCTIS2023-509908-15-00
BeOne Medicines AGMantle Cell Lymphoma
Start: 2020-01-20Target: 267Updated: 2025-10-17
Multicentric phase II trial to evaluate the efficacy and safety of Ibrutinib in combination with rituximab in patients with indolent clinical forms of Mantle Cell Lymphoma.
Not yet recruitingCTIS2024-512370-94-00
Fundacion GeltamoMantle Cell Lymphoma
Target: 50Updated: 2025-12-12
Long-term follow-up of patients previously treated with autologous T cells genetically modified with viral vectors.
RecruitingCTIS2024-511684-28-00
Autolus LimitedPotential malignancy in patients who received treatment with Autolus CAR T cell therapy.
Start: 2025-09-01Target: 21Updated: 2025-06-26
RIFIREINS. Rituximab from the first episode of Minimal Change Nephrotic Syndrome for preventing relapse risk in adult patients
RecruitingCTIS2024-516102-36-00
Assistance Publique Hopitaux De ParisMinimal Change Nephrotic Syndrom
Start: 2020-07-29Target: 148Updated: 2025-02-26
A Phase 2, Open-Label, Randomized, Multicenter Study of KYV101, an Autologous Fully Human Anti-CD19 Chimeric Antigen Receptor T Cell (CD19 CAR T) Therapy, in Subjects with Refractory Primary and Secondary Progressive Multiple Sclerosis (KYSA-7)
Not yet recruitingCTIS2024-511168-10-00
Kyverna Therapeutics Inc.Primary or Secondary Progressive Multiple Sclerosis
Target: 88Updated: 2024-10-07
A prospective, multicenter, phase II trial to assess the efficacy and safety of MRD-driven treatment with VEnetoclax and RItuximab combination in previously unTreated pAtients with chronic lymphocytic leukemia (VERITA PALG-CLL5 study)
Active, not recruitingCTIS2024-518494-34-00
Polish Adult Leukemia GroupChronic lymphocytic leukemia
Start: 2022-02-24Target: 103Updated: 2024-12-02
Chemoimmunotherapy in conjunction with blood-brain-barrier opening in patients with newly diagnosed or relapsed primary central nervous system lymphoma
Not yet recruitingCTIS2024-519046-79-00
Oulu University Hospitalensilinjan hoito tai hoito relapoituneessa tai refraktaarissa taudissa, Primaari aivolymfomaa
Target: 100Updated: 2024-12-20
VEMURAFENIB PLUS RITUXIMAB AS A CHEMOTHERAPY-FREE ALTERNATIVE TO CLADRIBINE FOLLOWED BY MRD-GUIDED RITUXIMAB IN FRONT-LINE HAIRY CELL LEUKEMIA (HCL): A PHASE-2 RANDOMIZED MULTICENTER TRIAL
RecruitingCTIS2024-520119-41-00
Universita' Degli Studi Di PerugiaPreviously untreated patients with diagnosis of HCL
Start: 2023-01-15Target: 120Updated: 2025-12-10
International multicentric phase II trial to evaluate the efficacy and safety of pirtobrutinib in combination with rituximab in patients with indolent clinical forms of Mantle Cell Lymphoma
RecruitingCTIS2024-511983-97-00
Fundacion GeltamoAdult patients with indolent MCL who have not previously received treatment (naïve patients).
Start: 2025-09-29Target: 50Updated: 2025-06-24

Phase 3

SYMPHONY-1: A PHASE 1B/3 DOUBLE-BLIND, RANDOMIZED, ACTIVE-CONTROLLED, 3-STAGE, BIOMARKER ADAPTIVE STUDY OF TAZEMETOSTAT OR PLACEBO IN COMBINATION WITH LENALIDOMIDE PLUS RITUXIMAB IN SUBJECTS WITH RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA
RecruitingCTIS2024-510690-16-00
Epizyme Inc.Relapsed/refractory follicular lymphoma
Start: 2022-01-31Target: 226Updated: 2025-06-26
Early rituximab treatment in children with idiopathic nephrotic syndrome Eng. ERICONS - Early RITUXIMAB in Childhood Onset Nephrotic Syndrome
RecruitingCTIS2024-515058-26-00
Medical University Of GdanskNEPHROTIC SYNDROME
Start: 2021-12-17Target: 60Updated: 2025-11-14
A Phase 3, Open-Label, Randomized Study of BGB-16673 Compared to Investigator’s Choice (Idelalisib Plus Rituximab or Bendamustine Plus Rituximab or Venetoclax Plus Rituximab Retreatment) in Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both BTK and BCL2 Inhibitors
RecruitingCTIS2024-518893-15-00
BeOne Medicines AGChronic lymphotic leukemia and Small Lymphocytic lymphoma
Start: 2025-07-29Target: 56Updated: 2026-01-14
A Phase 3 Randomized, Open-Label, Multicenter Study of Sonrotoclax Plus Anti-CD20 Antibody Therapies Versus Venetoclax Plus Rituximab in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
RecruitingCTIS2024-517131-52-00
BeOne Medicines AGRelapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Start: 2025-11-03Target: 285Updated: 2025-12-02
A prospective, open-label, randomized, multicenter phase-III trial to evaluate the efficacy of pirtobrutinib and epcoritamab compared with R-(mini)-CHOP for treatment of patients with Richter Transformation - CLLRT2
Not yet recruitingCTIS2024-513445-37-00
University Of Cologneirrespective of risk factors and disease stage, previously untreated RT
Target: 41Updated: 2026-03-18

Phase 4

Related Papers