LysaKare 25 g/25 g solution for infusion
Sponsors
Karolinska University Hospital, Advanced Accelerator Applications, Institut Regional Du Cancer De Montpellier, Pentixapharm AG, Centre Hospitalier Universitaire De Bordeaux
Conditions
Central nervous system (CNS) lymphoma; recurrent or refractory primary or isolated secondaryGastroenteropancreatic neuroendocrine tumor (GEP-NET)Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) in adultsNeuroblastomaNeuroendocrine tumorPatients with somatostatin receptor positiveRecurrent or refractory neuroblastoma.advanced GEP NETs
Phase 1
An open-label dose escalation study to evaluate safety, tolerability, biodistribution and efficacy of [90Y]Y-PentixaTher for the therapy of recurrent or refractory primary or isolated secondary central nervous system lymphoma
RecruitingCTIS2024-512097-98-00
Start: 2023-11-07Target: 15Updated: 2026-01-27
A Phase I Clinical Study Evaluating the Safety of Peptide Receptor Radionuclide Therapy (PRRT) with 177Lu-DOTA0-Tyr3-Octreotate in Children with Refractory or Recurrent Neuroblastoma expressing somatostatin receptors
RecruitingCTIS2024-515552-21-00
Start: 2023-04-17Target: 18Updated: 2025-10-08
Phase 2
A phase II trial of 177Lutetium-DOTATATE in children with primary refractory or relapsed high-risk neuroblastoma
LuDO-N
SuspendedCTIS2023-503684-42-00
Start: 2021-01-12Target: 31Updated: 2024-10-18
A PROSPECTIVE RANDOMIZED PHASE II STUDY TO ASSESS THE SCHEMAS OF RETREATMENT WITH LUTATHERA® ([177LU]LU-DOTA-TATE) IN PATIENTS WITH NEW PROGRESSION OF INTESTINAL WELL-DIFFERENTIATED NEUROENDOCRINE TUMOR
RecruitingCTIS2024-511001-28-00
Start: 2021-12-13Target: 176Updated: 2025-05-09
A multicenter open-label study to evaluate safety and dosimetry of Lutathera in adolescent patients with somatostatin receptor positive gastroenteropancreatic neuroendocrine (GEP-NET) tumors, pheochromocytoma and paragangliomas
Active, not recruitingCTIS2023-507444-37-00
Start: 2021-04-21Target: 5Updated: 2024-08-06
"Imaging with 68Ga-DOTA-peptides and peptide receptor radionuclide therapy with 177Lu-DOTA-peptides of gastroenteropancreatic neuroendocrine tumors: interest of intra-arterial hepatic infusion in patients with dominant liver metastases" "LUTARTERIAL"
RecruitingCTIS2024-514785-39-00
Start: 2021-09-24Target: 23Updated: 2024-11-04
Phase 3
A phase III multi-center, randomized, open-label study to evaluate the efficacy and safety of Lutathera in patients with Grade 2 and Grade 3 advanced GEP-NET (NETTER-2)
Active, not recruitingCTIS2023-507443-10-00
Start: 2019-11-04Target: 90Updated: 2025-11-19
A phase III multi-center, randomized, open-label study to evaluate the efficacy and safety of [177Lu]Lu-DOTA-TATE in patients newly diagnosed with Grade 1 and Grade 2 (Ki-67 <10%) advanced GEP-NET with high disease burden (NETTER-3)
RecruitingCTIS2024-518325-15-00
Start: 2025-09-08Target: 99Updated: 2025-12-09