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Luteinizing hormone-releasing hormone (LHRH) agonist

DRUG4 trials

Sponsors

University of Washington, Sidney Kimmel Cancer Center at Thomas Jefferson University, AstraZeneca

Conditions

ER-Positive HER2-Negative Breast CancerProstate Cancer

Phase 1

Cabazitaxel With Radiation and Hormone Therapy for Prostate Cancer
CompletedNCT01420250
Sidney Kimmel Cancer Center at Thomas Jefferson UniversityProstate Cancer
Start: 2011-09-22End: 2020-07-21Updated: 2025-05-15

Phase 2

Exisulind and Intermittent Androgen Suppression (ADT) in Biochemical Relapsed Prostate Cancer
CompletedNCT00283803
University of WashingtonProstate Cancer
Start: 2002-03-12End: 2011-10-31Updated: 2018-08-07

Phase 3

A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease
Active, not recruitingNCT04711252
AstraZenecaER-Positive HER2-Negative Breast Cancer
Start: 2021-01-28End: 2029-02-01Updated: 2025-10-14
Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6)
Active, not recruitingNCT04964934
AstraZenecaER-Positive HER2-Negative Breast Cancer
Start: 2021-06-30End: 2028-09-01Updated: 2026-07-14

Related Papers

SERENA-6 visual patient-reported outcomes & safety: camizestrant for emerging ESR1m advanced breast cancer during first-line endocrine-based therapy.
2026-07-24
Switching to camizestrant at ESR1 mutation emergence before disease progression during first-line treatment of hormone receptor-positive advanced breast cancer (SERENA-6): extended analysis of a double-blind, placebo-controlled, randomised, phase 3 trial.
2026-07-13
First-line (1L) camizestrant (CAMI) for emergent <i>ESR1</i> mutations ( <i>ESR1</i> m) in advanced breast cancer (ABC): Final progression-free survival 2 (PFS2) from the phase III SERENA-6 trial.
Journal of Clinical Oncology2026-06-03
Estimating meaningful change thresholds (MCTs) for selected scales from the European Organisation for Research and Treatment of Cancer (EORTC) questionnaires in the phase 3 SERENA-6 trial in patients with hormone receptor-positive/human epidermal growth factor receptor 2–negative advanced breast cancer (ABC).
JCO Oncology Practice2025-10-01
Abstract P5-06-17: The addition of ribociclib, palbociclib or abemaciclib to the next generation oral SERD, camizestrant, delivers greater anti-tumour efficacy in a range of ESR1wt and ESR1m breast PDX models
Clinical Cancer Research2025-06-13
Abstract PS7-08: Results from SERENA-1 Parts K/L: A Phase 1 study of the next-generation oral selective estrogen receptor degrader (SERD) camizestrant (AZD9833) in combination with ribociclib in women with ER-positive, HER2 negative advanced breast cancer
Clinical Cancer Research2025-06-13
Camizestrant + CDK4/6 inhibitor (CDK4/6i) for the treatment of emergent <i>ESR1</i> mutations during first-line (1L) endocrine-based therapy (ET) and ahead of disease progression in patients (pts) with HR+/HER2– advanced breast cancer (ABC): Phase 3, double-blind ctDNA-guided SERENA-6 trial.
Journal of Clinical Oncology2025-06-0414 citations
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Design of SERENA-6, a phase III switching trial of camizestrant in <i>ESR1</i> -mutant breast cancer during first-line treatment
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Abstract P3-07-13: The next generation oral selective estrogen receptor degrader (SERD) camizestrant (AZD9833) is active against wild type and mutant estrogen receptor α
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Implementation of CDK4/6 Inhibitors and its Influence on the Treatment Landscape of Advanced Breast Cancer Patients – Data from the Real-World Registry PRAEGNANT
Geburtshilfe und Frauenheilkunde2022-07-1228 citations
Serena-1: Updated analyses from a phase 1 study (parts C/D) of the next-generation oral SERD camizestrant (AZD9833) in combination with palbociclib, in women with ER-positive, HER2-negative advanced breast cancer.
Journal of Clinical Oncology2022-06-0140 citations
Abstract OT2-11-06: SERENA-4: A Phase III comparison of AZD9833 (camizestrant) plus palbociclib, versus anastrozole plus palbociclib, for patients with ER-positive/HER2-negative advanced breast cancer who have not previously received systemic treatment for advanced disease
Cancer Research2022-02-1512 citations
SERENA-4: A phase 3 comparison of AZD9833 (camizestrant) plus palbociclib, versus anastrozole plus palbociclib, for patients with ER-positive, HER2-negative advanced breast cancer who have not previously received systemic treatment for advanced disease.
Journal of Clinical Oncology2021-05-2025 citations
Phase I trial of weekly cabazitaxel with concurrent intensity-modulated radiation therapy (IMRT) and androgen deprivation therapy (ADT) for the treatment of high-risk prostate cancer (PCa).
Journal of Clinical Oncology2015-03-011 citations

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