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Lutathera 370 MBq/mL solution for infusion

DRUG13 trials

Sponsors

Karolinska University Hospital, Advanced Accelerator Applications, CHRU De Nancy, Institut Regional Du Cancer De Montpellier, Swiss Group for Clinical Cancer Research

Conditions

Gastroenteropancreatic neuroendocrine tumor (GEP-NET)Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) in adultsLocoregionally restricted (stage III) small intestinal neuroendocrine neoplasms (SI-NEN)Metastatic castration-resistant prostate cancerNeuroblastomaNeuroendocrine tumorNeuroendocrine tumors of midgut originPatients with somatostatin receptor positive

Phase 1

Phase 2

A phase II trial of 177Lutetium-DOTATATE in children with primary refractory or relapsed high-risk neuroblastoma LuDO-N
SuspendedCTIS2023-503684-42-00
Karolinska University HospitalNeuroblastoma
Start: 2021-01-12Target: 31Updated: 2024-10-18
A PROSPECTIVE RANDOMIZED PHASE II STUDY TO ASSESS THE SCHEMAS OF RETREATMENT WITH LUTATHERA® ([177LU]LU-DOTA-TATE) IN PATIENTS WITH NEW PROGRESSION OF INTESTINAL WELL-DIFFERENTIATED NEUROENDOCRINE TUMOR
RecruitingCTIS2024-511001-28-00
Institut Regional Du Cancer De MontpellierNeuroendocrine tumor
Start: 2021-12-13Target: 176Updated: 2025-05-09
Evaluation of the addition of Everolimus to 177Lu-DOTATATE in the treatment of grades 2 and 3 refractory meningioma: a phase IIb clinical trial
RecruitingCTIS2023-508400-38-00
CHRU De Nancymeningioma
Start: 2024-11-29Target: 28Updated: 2025-09-08
A multicenter open-label study to evaluate safety and dosimetry of Lutathera in adolescent patients with somatostatin receptor positive gastroenteropancreatic neuroendocrine (GEP-NET) tumors, pheochromocytoma and paragangliomas
Active, not recruitingCTIS2023-507444-37-00
Advanced Accelerator Applicationspheochromocytoma and paragangliomas, somatostatin receptor positive gastroenteropancreatic neuroendocrine (GEP-NET) tumors
Start: 2021-04-21Target: 5Updated: 2024-08-06
Single-arm open-label phase II study in children and adolescents of 177Lu-DOTATATE (Lutathera®) combined with the PARP inhibitor olaparib for treatment of recurrent or relapsed solid tumours expressing somatostatin receptor (SSTR) (LuPARPed).
Active, not recruitingCTIS2024-512613-40-00
Fundacion De investigacion De Hm HospitalesRecurrent or relapsed solid tumours expressing somatostatin receptors
Start: 2024-08-28Target: 27Updated: 2025-01-20
"Imaging with 68Ga-DOTA-peptides and peptide receptor radionuclide therapy with 177Lu-DOTA-peptides of gastroenteropancreatic neuroendocrine tumors: interest of intra-arterial hepatic infusion in patients with dominant liver metastases" "LUTARTERIAL"
RecruitingCTIS2024-514785-39-00
Centre Hospitalier Universitaire De BordeauxGastroenteropancreatic neuroendocrine tumours (GEP-NETs) in adults
Start: 2021-09-24Target: 23Updated: 2024-11-04
EORTC 2334-BTG: [177Lu]Lu-DOTATATE for recurrent MENingioma (LUMEN-1): a randomized phase II study
RecruitingCTIS2024-513443-93-00
Europese Organisatie Voor Onderzoek En Behandeling Van Kanker Organisation Europeenne Pour La Recherche Et Le Traitement Du Cancer European OrganiRecurrent Meningioma without local treatment options (Surgery or Radiotherapy)
Start: 2025-03-10Target: 61Updated: 2026-01-16
SAKK 08/23: Addition of Darolutamide to first line treatment of mCRPC: a randomized open label phase II trial
RecruitingCTIS2024-512132-29-00
Swiss Group for Clinical Cancer ResearchMetastatic castration-resistant prostate cancer
Start: 2025-08-06Target: 100Updated: 2025-05-22

Phase 3