Lumacaftor
Sponsors
Vertex Pharmaceuticals Incorporated
Conditions
Advanced Lung DiseaseCystic Fibrosis
Phase 1
A Phase 1 Study to Examine the Drug-Drug Interaction of Ciprofloxacin, Itraconazole, and Rifampin on the Combination of Lumacaftor With Ivacaftor in Healthy Adult Subjects
CompletedNCT01768663
Start: 2013-01-31Updated: 2013-11-15
A Phase 1 Study to Investigate the Food Effect of Lumacaftor in Combination With Ivacaftor
CompletedNCT01899105
Start: 2013-07-31End: 2013-08-31Updated: 2014-04-03
Phase 1, QT/QTC Interval Study in Healthy Subjects
CompletedNCT01910415
Start: 2013-06-30End: 2014-03-31Updated: 2014-08-11
Phase 2
Phase 3
Study of Lumacaftor in Combination With Ivacaftor in Subjects 6 Through 11 Years of Age With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation
CompletedNCT01897233
Start: 2013-07-31End: 2015-10-31Updated: 2017-06-20
Study to Evaluate Lumacaftor and Ivacaftor Combination Therapy in Subjects 12 Years and Older With Advanced Lung Disease
CompletedNCT02390219
Start: 2015-03-31End: 2016-10-31Updated: 2017-12-06